期刊论文

Peng, Q.H.

中文

中国中西医结合杂志

1003-5370

2012

32

1

72-75,114

国家自然科学基金面上资助项目（No.30772824）； 教育部高等学校博士学科点专项科研基金资助项目（No.200805410004）； 湖南省自然科学基金资助项目（No.07JJ3049）； 湖南省科技厅科研基金资助项目（No.2009FJ3001）；

本校为第一机构

目的观察密蒙花提取物滴眼剂对去势所致干眼症雄鼠基础泪液分泌量、泪膜稳定性及泪腺中雄激素受体(AR)表达的影响, 探讨密蒙花提取物滴眼剂抗雄激素水平下降所致干眼症的作用机制。方法将45只Wistar雄性大鼠随机分为空白组、模型组、密蒙花提取物滴眼剂治疗组(治疗组), 每组又分为饲养1、2、3个月的3个亚组, 共9组, 每组5只, 模型组及治疗组行去势术建立动物模型, 治疗组以密蒙花提取物滴眼剂连续滴眼治疗1个月, 对大鼠行Schirmer Ⅰ试验(SIT)、测量泪膜破裂时间(BUT), 采用流式细胞仪检测泪腺中AR的表达。结果模型组1、2、3个月亚组SIT值、BUT及AR表达低于同期空白组(P

OBJECTIVE: To observe the effects of the extract of Buddleja officinalis eye drops (EBOED) on basic tears secretory volume, tear film stability, and expressions of androgen receptors (AR) in castrated rats with dry eye, and to investigate the mechanism of EBOED on dry eye caused by decreased anti-androgen levels. METHODS: Forty-five male Wistar rats were randomly divided into the blank group, the model group, and the treatment group (treated by EBOED), respectively. Rats in each group were further divided into three sub-groups (fed for one month, two months, and three months, respectively). Th...