版权说明 操作指南
首页 > 成果 > 详情

Notch3 deficiency impairs coronary microvascular maturation and reduces cardiac recovery after myocardial ischemia

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Tao, Yong-Kang;Zeng, Heng;Zhang, Guo-Qiang;Chen, Sean T.;Xie, Xue-Jiao;...
通讯作者:
Chen, JX;Zhang, GQ
作者机构:
[Wang, Shuo; Zeng, Heng; Chen, Jian-Xiong; He, Xiaochen; Xie, Xue-Jiao; Tao, Yong-Kang] Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, 2500 North State St, Jackson, MS 39216 USA.
[Zhang, Guo-Qiang; Tao, Yong-Kang] China Japan Friendship Hosp, Emergency Dept, Beijing 100029, Peoples R China.
[Chen, Jian-Xiong; Wen, Hongyan; Xie, Xue-Jiao] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.
[Chen, Sean T.] Duke Univ, Sch Med, Durham, NC 27706 USA.
通讯机构:
[Chen, JX ] U
[Zhang, GQ ] C
Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, 2500 North State St, Jackson, MS 39216 USA.
China Japan Friendship Hosp, Emergency Dept, Beijing 100029, Peoples R China.
语种:
英文
关键词:
angiogenic factor;angiopoietin 1;CD11b antigen;chemokine receptor CXCR4;intercellular adhesion molecule 2;neural glial antigen 2;Notch3 receptor;proteoglycan;stem cell antigen 1;stem cell factor receptor;unclassified drug;vasculotropin;Notch3 protein, mouse;Notch3 receptor;animal experiment;animal model;animal tissue;arteriole;Article;cardiac functional recovery;cell infiltration;controlled study;coronary artery ligation;coronary flow reserve;coronary microvascular maturation;disease predisposition;echocardiography;heart function;heart infarction size;heart muscle capillary;heart muscle ischemia;knockout mouse;left anterior descending coronary artery;macrophage;microvascularization;mortality;mouse;mouse model;nonhuman;pericyte;prognosis;protein deficiency;protein expression;protein function;wild type mouse;animal;C57BL mouse;convalescence;coronary artery blood flow;coronary blood vessel;deficiency;heart muscle ischemia;male;metabolism;microvasculature;pathology;pathophysiology;physiology;Animals;Coronary Circulation;Coronary Vessels;Male;Mice;Mice, Inbred C57BL;Mice, Knockout;Microvessels;Myocardial Ischemia;Receptor, Notch3;Recovery of Function
期刊:
International Journal of Cardiology
ISSN:
0167-5273
年:
2017
卷:
236
页码:
413-422
基金类别:
This study was supported by grants from NIH grant 2R01HL102042-05 and University of Mississippi Medical Center Intramural Research Support Program to J.X. Chen
机构署名:
本校为其他机构
摘要:
Rationale Vascular maturation plays an important role in wound repair post-myocardial infarction (MI). The Notch3 is critical for pericyte recruitment and vascular maturation during embryonic development. Objective This study is to test whether Notch3 deficiency impairs vascular maturation and blunts cardiac functional recovery post-MI. Approach and results Wild type (WT) and Notch3 knockout (Notch3KO) mice were subjected to MI by the ligation of left anterior descending coronary artery (LAD). Cardiac function and coronary blood flow reserve (C...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com