Proprotein convertase subtilisin/kexin type 9 （PCSK9） is closely related to modulate plasma cholesterol metabolism as newly discovered, and belongs to the proprotein convertase （PC） family. PCSK9 is a protein that reduces risk of coronary artery disease, peripheral vascular disease, cerebrovascular disease, nervous system diseases and diabetes by lowering serum low density lipoprotein cholesterol （LDLC） levels. Recent studies have shown that PCSK9 polymor- phisms may modulate plasma cholesterol levels either positively or negatively. Reco...
