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Effects of total saponins of Panax notoginseng on immature neuroblasts in the adult olfactory bulb following global cerebral ischemia/reperfusion

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成果类型:
期刊论文
作者:
He, Xu;Deng, Feng-jun;Ge, Jin-wen(葛金文);Yan, Xiao-xin;Pan, Ai-hua*;...
通讯作者:
Pan, Ai-hua
作者机构:
[He, Xu; Yan, Xiao-xin; Pan, Ai-hua; Li, Zhi-yuan] Cent S Univ, Dept Anat & Neurobiol, Sch Basic Med Sci, Changsha, Hunan, Peoples R China.
[He, Xu] Yiyang Med Coll, Dept Anat, Yiyang, Hunan, Peoples R China.
[Deng, Feng-jun] Yiyang Med Coll, Dept Pharm, Yiyang, Hunan, Peoples R China.
[Ge, Jin-wen] Hunan Univ Tradit Chinese Med, Dept Integrated Tradit & Western Med, Changsha, Hunan, Peoples R China.
通讯机构:
[Pan, Ai-hua] C
Cent S Univ, Dept Anat & Neurobiol, Sch Basic Med Sci, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
nerve regeneration;total saponins of Panax notoginseng;cerebral ischemia/reperfusion;immature neurons;neurogenesis;doublecortin;olfactory bulb;neural regeneration
关键词(中文):
缺血/再灌注;三七总皂苷;神经行为;脑血流;母细胞;嗅球;成熟;脑缺血再灌注
期刊:
中国神经再生研究:英文版
ISSN:
1673-5374
年:
2015
卷:
10
期:
9
页码:
1450-1456
基金类别:
ZYL and AHP designed the study. XH, FJD, and JWG implemented the experiments. XH wrote and revised the paper. XXY analyzed the data and supervised the whole research. All authors approved the final version of the paper. Conflicts of interest: None declared.
机构署名:
本校为其他机构
院系归属:
中西医结合学院
摘要:
The main active components extracted from Panax notoginseng are total saponins. They have been shown to inhibit platelet aggregation, increase cerebral blood flow, improve neurological behavior, decrease infarct volume and promote proliferation and differentiation of neural stem cells in the hippocampus and lateral ventricles. However, there is a lack of studies on whether total saponins of Panax notoginseng have potential benefits on immature neuroblasts in the olfactory bulb following ischemia and reperfusion. This study established a rat model of global cerebral ischemia and reperfusion usi...

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