Inhibition of aortic intimal hyperplasia and cell cycle protein and extracellular matrix protein expressions by BuYang HuanWu Decoction

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成果类型：

期刊论文

作者：

Wu, Lu;Zhang, Wei;Li, Hua（李花）;Chen, Bei-Yang;Zhang, Guo-Min;...

通讯作者：

Deng, Chang-Qing（邓常清）

作者机构：

[Wu, Lu] Hunan Univ Tradit Chinese Med, Affiliated Tradit & Western Med Hosp 2, Changsha, Hunan, Peoples R China.

[Deng, Chang-Qing; Zhang, Wei] Hunan Univ Tradit Chinese Med, Pathophysiol Lab, Changsha, Hunan, Peoples R China.

[Li, Hua; Zhang, Guo-Min; Chen, Bei-Yang] Hunan Univ Tradit Chinese Med, Dept Pathol, Changsha, Hunan, Peoples R China.

[Tang, Ying-Hong] Hunan Univ Tradit Chinese Med, Dept Pharmacol, Changsha, Hunan, Peoples R China.

[He, Fu-Yuan] Hunan Univ Tradit Chinese Med, Dept Pharmaceut, Changsha, Hunan, Peoples R China.

通讯机构：

[Deng, Chang-Qing] H

Hunan Univ Tradit Chinese Med, Pathophysiol Lab, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

BuYang HuanWu Decoction;Atorvastatin;Vascular intimal hyperplasia;Vascular smooth muscle cell;Morphology;Proliferating cell nuclear antigen;CyclinD(1);CyclinE;Extracellular matrix;Collagen I;Fibronectin

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2009

卷：

125

期：

页码：

423-435

DOI：

10.1016/j.jep.2009.07.022

基金类别：

National Natural Science Foundation of China [30572301]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

中医学院

药学院

摘要：

Aim of the study: The inhibitive effect of BuYang HuanWu Decoction (BYHWD) and its major components on vascular intimal hyperplasia and the expressions of cell cycle protein and extracellular matrix protein. Materials and methods: Sprague-Dawley rats were randomly divided into sham-operated, control, alkaloid, glycoside, BYHWD and atorvastatin groups. Rat aorta intima in all groups were injured by insesion of domestic balloon catheter into the aortae except sham-operated rats. Drugs were administrated orally from the second day after vascular injury and continued for 14 days. The injured segme...

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Inhibition of aortic intimal hyperplasia and cell cycle protein and extracellular matrix protein expressions by BuYang HuanWu Decoction

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