期刊论文

Ma, H.X.

中文

中药材

1001-4454

2008

31

11

1706-1709

10.13863/j.issn1001-4454.2008.11.050

广东省自然科学基金（5300997） 广州市卫生局项目（2005A041）

本校为其他机构

目的:观察菟丝子总黄酮对大鼠流产模型母-胎界面Fas/FasL、PCNA、HB-EGF表达的影响.方法:对溴隐亭致SD孕鼠流产模型,以菟丝子总黄酮高、低剂量为治疗组,达芙通为阳性对照组,于孕12 d处死各组大鼠,应用免疫组织化学方法检测胎盘和蜕膜Fas/FasL、PCNA、HB-EGF的表达.结果:菟丝子总黄酮高、低剂量组、达芙通及正常妊娠组蜕膜和胎盘PCNA表达显著高于模型组,蜕膜和胎盘Fas/FasL表达显著低于模型组,胎盘HB-EGF表达显著高于模型组,差异均有显著性,菟丝子总黄酮高、低剂量组与孕激素达芙通组比较,差异无显著性,各组蜕膜皆无HB-EGF表达.结论:菟丝子总黄酮可能通过调节滋养细胞的增殖与凋亡,使其恢复到正常...

OBJECTIVE: To explore the effect of total flavones from cuscuta chinensis (TFCC) on expression of Fas, PCNA and HB-EGF in SD rats model with bromocriptine-induced abortion. METHODS: The model rats of bromocriptine during 6-8 d of pregnancy induced early abortion was established, adopting respectively herbs in high and low dosage and progesterone affect model rat and after 12 d, Immunohistochemical was applied to determine Fas, HB-EGF and PCNA in deciduas and placenta. RESULTS: Expression of PCNA on trophoblast and deciduas, HB-EGF on trophoblast, PR on deciduas in the model used Semen cuscutae...