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Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer.

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成果类型:
期刊论文
作者:
Wang, Zhiqi;Li, Sai;Cao, Yu;Tian, Xuefei;Zeng, Rong;Liao, Duan-Fang;Cao, Deliang
通讯作者:
Cao, Deliang(dcao@siumed.edu)
作者机构:
[Tian, Xuefei; Wang, Zhiqi; Li, Sai; Liao, Duan-Fang; Cao, Deliang; Zeng, Rong] Hunan Univ Chinese Med, Dept Pharmacol, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha 410208, Hunan, Peoples R China.
[Tian, Xuefei; Wang, Zhiqi; Li, Sai; Liao, Duan-Fang; Cao, Deliang; Zeng, Rong] Hunan Univ Chinese Med, Key Lab Coll, Changsha 410208, Hunan, Peoples R China.
[Tian, Xuefei; Wang, Zhiqi; Li, Sai; Liao, Duan-Fang; Cao, Deliang; Zeng, Rong] Hunan Univ Chinese Med, Univ Hunan Prov Cytobiol & Mol Biotechnol, Changsha 410208, Hunan, Peoples R China.
[Cao, Yu; Cao, Deliang] So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, 913 N Rutledge St, Springfield, IL 62794 USA.
通讯机构:
[Cao, Deliang] Hunan Univ Chinese Med, Dept Pharmacol, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha 410208, Hunan, Peoples R China.
[Cao, Deliang] Hunan Univ Chinese Med, Key Lab Coll, Changsha 410208, Hunan, Peoples R China.
[Cao, Deliang] Hunan Univ Chinese Med, Univ Hunan Prov Cytobiol & Mol Biotechnol, Changsha 410208, Hunan, Peoples R China.
[Cao, Deliang] So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, 913 N Rutledge St, Springfield, IL 62794 USA.
语种:
英文
关键词:
Aldo-keto reductase - Chemical messengers - Inflammatory conditions - Lipid peroxidation - Malignant progression - Pathogenic factors - Reactive oxygen species - Ulcerative colitis
期刊:
Oxidative Medicine and Cellular Longevity
ISSN:
1942-0900
年:
2016
卷:
2016
页码:
9875298
文献类别:
WOS:Review;EI:Journal article (JA)
所属学科:
ESI学科类别:分子生物学&遗传学;WOS学科类别:Cell Biology
入藏号:
WOS:000371504200001;EI:20160601907899;PMID:26823956
基金类别:
Hunan Engineering Center for Rapid Test and Removal of Toxic and Harmful Substances in Chinese Medicine [201303]; National Natural Science Foundation of China [81503492, 81272918, 81472465]
机构署名:
本校为第一且通讯机构
院系归属:
中西医结合学院
药学院
摘要:
Oxidative stress has long been known as a pathogenic factor of ulcerative colitis (UC) and colitis-associated colorectal cancer (CAC), but the effects of secondary carbonyl lesions receive less emphasis. In inflammatory conditions, reactive oxygen species (ROS), such as superoxide anion free radical (O 2 -), hydrogen peroxide (H<inf>2</inf>O<inf>2</inf>), and hydroxyl radical (H O ), are produced at high levels and accumulated to cause oxidative stress (OS). In oxidative status, accumulated ROS can cause protein dysfunction and DNA damage, leading to gene mutations and cell death. Accumulated ROS could also act as chemical messengers to activate signaling pathways, such as NF-B and p38 MAPK, to affect cell proliferation, differentiation, and apoptosis. More importantly, electrophilic carbonyl compounds produced by lipid peroxidation may function as secondary pathogenic factors, causing further protein and membrane lesions. This may in turn exaggerate oxidative stress, forming a vicious cycle. Electrophilic carbonyls could also cause DNA mutations and breaks, driving malignant progression of UC. The secondary lesions caused by carbonyl compounds may be exceptionally important in the case of host carbonyl defensive system deficit, such as aldo-keto reductase 1B10 deficiency. This review article updates the current understanding of oxidative stress and carbonyl lesions in the development and progression of UC and CAC. &copy;2016 Zhiqi Wang et al.
参考文献:
Agarwal ML, 1998, J BIOL CHEM, V273, P1, DOI 10.1074/jbc.273.1.1
de la Lastral CA, 2007, BIOCHEM SOC T, V35, P1156
Allez M, 2009, ALIMENT PHARM THER, V31, P92, DOI 10.1111/j.1365-2036.2009.04130.x
ALVAREZ JG, 1984, BIOL REPROD, V30, P323, DOI 10.1095/biolreprod30.2.323
AMES BN, 1983, SCIENCE, V221, P1256, DOI 10.1126/science.6351251

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