IMM-H004, a Novel Coumarin Derivative Compound, Inhibits H2O2-Induced Neurotoxicity via Antioxidant and Antiapoptosis in PC12 Cells

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成果类型：

期刊论文

作者：

Song, Xiu-Yun;Hu, Jin-Feng;Wu, Dong-Hui;Ji, Hai-Jie;Chen, Nai-Hong*

通讯作者：

Chen, Nai-Hong

作者机构：

[Ji, Hai-Jie; Song, Xiu-Yun; Hu, Jin-Feng; Chen, Nai-Hong; Wu, Dong-Hui] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing, Peoples R China.

[Ji, Hai-Jie; Song, Xiu-Yun; Hu, Jin-Feng; Chen, Nai-Hong; Wu, Dong-Hui] Chinese Acad Med Sci, Neurosci Ctr, Beijing, Peoples R China.

[Ji, Hai-Jie; Song, Xiu-Yun; Hu, Jin-Feng; Chen, Nai-Hong; Wu, Dong-Hui] Peking Union Med Coll, 2 Nanwei Rd, Beijing 100050, Peoples R China.

[Chen, Nai-Hong] Hunan Univ Chinese Med, Coll Pharm, Changsha, Hunan, Peoples R China.

[Chen, Nai-Hong] Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, 2 Nanwei Rd, Beijing 100050, Peoples R China.

通讯机构：

[Chen, Nai-Hong] P

[Chen, Nai-Hong] C

Peking Union Med Coll, 2 Nanwei Rd, Beijing 100050, Peoples R China.

Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, 2 Nanwei Rd, Beijing 100050, Peoples R China.

语种：

英文

关键词：

IMM-H004;apoptosis;coumarin;hydrogen peroxide;oxidative stress

期刊：

Journal of Stroke & Cerebrovascular Diseases

ISSN：

1052-3057

年：

2018

卷：

期：

页码：

3396-3403

DOI：

10.1016/j.jstrokecerebrovasdis.2018.05.022

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81603515, 81603316]; National Mega-project for Innovative Drugs [2012ZX09301002-004]; CAMS Initiative for Innovative Medicine [2016-I2M-1004]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

IMM-H004 [7-hydroxy-5-methoxy-4-methyl-3-(4-methylpiperazin-1-yl)-coumarin] is a novel derivative of coumarin, which played neuroprotective roles in brain ischemia in rats in previous studies. Although antiapoptosis and improving synapsis structure were proved, the effects and mechanisms of IMM-H004 in brain ischemia need further study. In this paper, the effect of IMM-H004 on H2O2-induced neurotoxicity in pheochromocytoma (PC12) cells was researched. Morphological observation, MTT method and PI/Hoechst staining were used to indicate cell viabi...

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IMM-H004, a Novel Coumarin Derivative Compound, Inhibits H2O2-Induced Neurotoxicity via Antioxidant and Antiapoptosis in PC12 Cells

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