期刊论文

Effect of Total Flavones from Cuscuta Chinensis on Immune Balance Factors of Maternal Fetus in Rat Model

中文

世界中西医结合杂志

1673-6613

2011

6

10

837-841

10.3969/j.issn.1673-6613.2011.10.005

广东省自然科学基金（No.5300997） 广州市卫生局资助研究项目（No.2005A041）

本校为其他机构

目的 观察中药菟丝子助孕安胎的免疫机理.方法 通过对溴隐亭致SD大鼠流产模型组织形态、母胎界面滋养细胞凋亡因子CD95分子及其配子(Fas/FasL)、增殖细胞核抗原(PCNA)、人肝素结合性表皮生长因子(HB-EGF)及妊娠免疫调节因子孕激素受体(PR)、催乳素(PRL)、孕酮(P)、辅助性T细胞Th1/Th2的变化,观察菟丝子总黄酮高、低剂量组、达芙通组各项指标的变化,免疫组化法检测胎盘和蜕膜Fas/FasL、PCNA、HB-EGF、PR的表达;RT-PCR法检测蜕膜Th1/Th2 mRNA的表达.结果 菟丝子高、低剂量治疗组、达芙通组胎仔数、HB-EGF、PCNA、白细胞介素4(IL-4)、白细胞介素10(IL-10)mRNA及PR表达显著高于流产模型组,流产率、F...

Objective To observe the immune mechanism of cuscuta chinensis on pregnancy and fetal protection.Methods The changes in histological morphology of the miscarriage model in SD rat induced by bromocriptine,trophoblasts apoptosis factor CD95 molecules in maternal-fetal interface and their gametes（Fas/FasL）,the proliferating cell nuclear antigen（PCNA）,the human heparin-binding epidermal growth factor（HB-EGF）and progesterone（P）and helper T cells（Th1/Th2）were observed in a high-dose group and a low-dose group of total flavones from cuscuta ...