期刊论文

Effect of alcohol intake on blood and intestinal microbiota and enzyme activities of mice

中文

微生物学通报

0253-2654

2018

45

7

1462-1469

10.13344/j.microbiol.china.170766

湖南省大学生研究性学习和创新性实验计划项目（1032） 长沙市科技局项目（kq1701071）

本校为第一机构

【背景】酒是影响机体健康的一把"双刃剑",饮酒对机体肠道微生态体系具有重要影响。【目的】研究不同酒精摄入量对小鼠肠道微生物、酶活性及血常规的影响,从肠道微生态和血常规角度探讨饮酒对身体健康的影响及作用机制。【方法】将SPF (Specific pathogen free)级实验小鼠随机分为对照组、低酒精量摄入组、中酒精量摄入组和高酒精量摄入组。对照组给予蒸馏水饮用,其余各组分别给予10%、20%和30% (体积比)的酒精水溶液作为小鼠的唯一饮用水,连续1个月后采集回肠内容物进行微生物和酶活性分析,采集眼球血进行血常规分析。【结果】与对照组相比,低酒精量摄入组小鼠肠道内乳酸菌数量显著增加(P

[Background] Alcohol affects people's health in two ways: beneficial or harmful. Influence of alcohol on the intestinal micro-ecological system is great. [Objective] Present study was to explore the influence of alcohol intake on blood, intestinal microbiota and enzyme activities of mice. [Methods] SPF (specific pathogen free) experimental mice were randomly divided into 4 groups: control group, low dose group, medium dose group and high dose group. Mice of the control group were given sterile water to drink, other groups were given 10%, 20% and 30% (V/V) ethanol solution respectively to drink...