期刊论文

中文

现代生物医学进展

1673-6273

2013

16

3193-3196

10.13241/j.cnki.pmb.2013.16.025

湖南省科学技术厅科技计划重点项目（2009SK2010）；

本校为其他机构

含凝血酶敏感素1型基序的解聚素样金属蛋白酶（a disintegrin and metalloproteinase with thrombospondin motifs 1,ADAMTS-1）可降解细胞外基质中的多能蛋白聚糖,促进平滑肌细胞的迁移,参与动脉粥样硬化的发生,并能进一步活化粥样斑块,促进斑块破裂;还可抑制血管的新生、参与胶原代谢加速心室重构、心肌纤维化等病理过程的进展,与各种类型的冠心病如稳定型心绞痛（stable angina,SA）、急性冠脉综合征（acute coronary syndrome,ACS）、缺血性心肌病（ischemic cardiomyopathy,ICM）均密切相关。研究表明,ADAMTS-1有助于冠脉狭窄程度评估、斑块稳定性判断、ACS的辅助诊断及治疗策略的选择,有望...

A disintegrin and metalloproteinase with thrombospondin motifs 1（ADAMTS-1） played a role in the development of atherosclerosis by cleaving extracellular matrix proteins such as versican,promoting vascular smooth muscle cells（VSMCs） migration and further activated atheromatous plaque to make it easy to burst.It was also involved in various pathological processes such as inhibiting the angiogenesis,participating in myocardial fibrosis and ventricular remodeling and closely related to different types of coronary heart diseases,such as stable a...