miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Lin-Zi;Zhang, Chris Zhiyi;Liu, Li-Li;Yi, Chun（易纯）;Lu, Shi-Xun;...

通讯作者：

Yun, Jing-Ping

作者机构：

[Yang, Yuan-Zhong; Zhang, Chris Zhiyi; Lu, Shi-Xun; Yun, Jing-Ping; Liu, Li-Li; Zhang, Zhao-Jie; Peng, Yi-Han; Li, Lin-Zi; Zhou, Xuan] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China.

[Yang, Yuan-Zhong; Zhang, Chris Zhiyi; Lu, Shi-Xun; Yun, Jing-Ping; Liu, Li-Li; Zhang, Zhao-Jie; Peng, Yi-Han; Li, Lin-Zi; Zhou, Xuan] Sun Yat Sen Univ, Ctr Canc, Dept Pathol, Guangzhou 510060, Guangdong, Peoples R China.

[Yi, Chun] Hunan Univ Chinese Med, Coll Med, Dept Pathol, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Yun, Jing-Ping] S

Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China.

语种：

英文

期刊：

Carcinogenesis

ISSN：

0143-3334

年：

2014

卷：

期：

页码：

469-478

DOI：

10.1093/carcin/bgt330

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372572, 81172345, 81201717]; State Key Laboratory of Oncology in South China

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Breast cancer is the leading cause of cancer death among females, with tumor metastasis being primarily responsible for breast cancer-associated mortality. Current literatures have shown that microRNAs (miRNAs) are implicated in tumor metastasis. In this study, we found that the expression of miR-720 was significantly downregulated in primary breast cancer, with greater downregulation in metastatic tumors. Statistical analysis of 105 cases of primary human breast cancer demonstrated that decreased expression of miR-720 was correlated with lymph...

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miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1

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