期刊论文

He, Ying-chun

英文

Journal of Zhejiang University. Science. B

浙江大学学报：B卷英文版

1673-1581

2009

10

3

172-179

10.1631/jzus.B0820186

Project supported by the National Natural Scicncc Foundation of China （Nos. 30672738, 30572455 and 30572408）, Hunan Provincial Natural Science Foundation for Distinguished Young Scholars （No. 03JJY 1006） and for General Projects （Nos. 05JJ40029 and 07JJ6038）, the Research Foundation of Hunan Provincial Scientific and Technological Department for International Cooperative Academic Projects （No. 06WK3016）, and the Research Foundation of Hunan Provincial Education Department for Outstanding Young Scholars （No. 06B070）, China

本校为第一且通讯机构

OBJECTIVE: To investigate the enhancive effect of N,N'-dinitrosopiperazine (DNP) on induced carcinogenesis in nasal and/or nasopharyngeal epithelia among TgN(p53mt-LMP1)/HT transgenic mice to examine the underlying mechanism for the development of nasopharyngeal carcinoma (NPC). METHODS: TgN(p53mt-LMP1)/HT transgenic mice and the same strain of C(57)BL/6J wild-type mice both at the age of 5 months were randomly divided into 2 groups in parallel, respectively, i.e., TgN(p53mt-LMP1)/HT cancerous lesion-inducing group (TI), TgN(p53mt-LMP1)/HT control group (TC), C57BL/6J cancerous lesion-inducing...

调查 N 的增加的效果的目的，在在 TgN (p53mt-LMP1 )/HT 之中的鼻音或鼻咽的 epithelia 的导致的 carcinogenesis 上的 N′-dinitrosopiperazine (DNP ) 为鼻咽的癌(NPC ) 的发展检验内在的机制的转基因的老鼠。转基因的老鼠和一样 C 57分别地， BL/6J 野类型的老鼠随机两个都在平行在 5 个月岁时被划分成 2 个组即， TgN ( p53mt-LMP1 ) /HT 癌的导致损害的组( TI )， TgN ( p53mt-LMP1 ) /HT 控制组( TC )， C 57 BL/6J 癌的导致损害的组( CI )，和 C 57 BL/6J 控制组( CC )。TI 和 CI 鼠标仅仅与 DNP 被对待 16 个星期，两次每个星期，当 TC 和 CC 鼠标被给一样的卷时象控制盐。在处理...