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NK cells in cerebral ischemia

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成果类型:
期刊论文
作者:
Chen, Chen;Ai, Qi-Di;Chu, Shi-Feng;Zhang, Zhao;Chen, Nai-Hong*
通讯作者:
Chen, Nai-Hong
作者机构:
[Chen, Chen; Chen, Nai-Hong; Zhang, Zhao; Chu, Shi-Feng] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.
[Chen, Chen; Chen, Nai-Hong; Zhang, Zhao; Chu, Shi-Feng] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.
[Chen, Chen; Chen, Nai-Hong; Zhang, Zhao; Chu, Shi-Feng] Peking Union Med Coll, 1 Xiannongtan St, Beijing 100050, Peoples R China.
[Ai, Qi-Di; Chen, Nai-Hong] Hunan Univ Tradit Chinese Med, Changsha 410208, Hunan, Peoples R China.
[Chen, Nai-Hong] Chinese Acad Med Sci, Inst Mat Med, Neurosci Ctr, State Key Lab Bioact Subst & Funct Nat Med, 1 Xiannongtan St, Beijing 100050, Peoples R China.
通讯机构:
[Chen, Nai-Hong] P
[Chen, Nai-Hong] C
Peking Union Med Coll, 1 Xiannongtan St, Beijing 100050, Peoples R China.
Chinese Acad Med Sci, Inst Mat Med, Neurosci Ctr, State Key Lab Bioact Subst & Funct Nat Med, 1 Xiannongtan St, Beijing 100050, Peoples R China.
语种:
英文
关键词:
NK cells;Cerebral ischemia;Inflammation;Immunodpression;Infection
期刊:
Biomedicine & Pharmacotherapy
ISSN:
0753-3322
年:
2019
卷:
109
页码:
547-554
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81730096, U1402221]; National Mega-project for Innovative Drugs [2018ZX09711001-002-007, 2018ZX09711001-003-005, 2018ZX09711001-009-013]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-004]; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study [BZ0150]; State Key Laboratory Fund Open Project [GTZK201610]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2013M540066]; Project of NDRC [60011000]; Hunan Provincial Key Laboratory for Standardization of Important Chinese Herbal Pieces [BG201701, 4981-0901020]; State Administration of Traditional Chinese Medicine [60011000]
机构署名:
本校为其他机构
摘要:
As a vital cell type in immune system and infiltrating cells in ischemic brain, NK cells can bridge the crosstalk between immune system and nervous system in stroke setting. The mechanism of action of NK cells is complicated, involving direct and indirect actions. NK cells are closely associated with poststroke inflammation, immunodepression and infections. The excessive inflammatory response in ischemic brain is one of the important causes for aggravating cerebral ischemic injury. Besides the inflammation induced by ischemia itself, thrombolytic drug tissue plasminogen activator (tPA) adminis...

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