版权说明 帮助中心
首页 > 成果 > 详情

ATP-binding membrane cassette transporter A1 (ABCA1): a possible link between inflammation and reverse cholesterol transport.

SCI-EMedline
WOS被引频次:75
认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Yin, Kai;Liao, Duan-fang;Tang, Chao-ke*
通讯作者:
Tang, Chao-ke
作者机构:
[Tang, Chao-ke; Yin, Kai] Univ S China, Inst Cardiovasc Res, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
[Liao, Duan-fang] Hunan Univ Chinese Med, Sch Pharm, Dept Tradit Chinese Diagnost, Changsha, Hunan, Peoples R China.
通讯机构:
[Tang, Chao-ke] Univ S China, Inst Cardiovasc Res, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
期刊:
Molecular medicine (Cambridge, Mass.)
ISSN:
1076-1551
年:
2010
卷:
16
期:
9-10
页码:
438-449
文献类别:
WOS:Article
所属学科:
ESI学科类别:分子生物学&遗传学;WOS学科类别:Biochemistry & Molecular Biology;Cell Biology;Medicine, Research & Experimental
入藏号:
WOS:000281595000013;PMID:20485864
基金类别:
National Natural Sciences Foundation of China [30470720]; Post-doctor Sciences Foundation of China [2005037157]; Hunan Provincial Natural Sciences Foundation of China [10JJ9019]
机构署名:
本校为其他机构
院系归属:
药学院
摘要:
Atherosclerosis is characterized by a chronic inflammatory condition that involves numerous cellular and molecular inflammatory components. A wide array of inflammatory mediators, such as cytokines and proteins produced by macrophages and other cells, play a critical role in the development and progression of the disease ATP-binding membrane cassette transporter A1 (ABCA1) is crucial for cellular cholesterol efflux and reverse cholesterol transport (RCT) and is also identified as an important target in antiatherosclerosis treatment Evidence from several recent studies indicates that inflammation, along with other atherogenic-related mediators, plays distinct regulating roles in ABCA1 expression Proatherogenic cytokines such as interferon (IFN)-gamma and interleukin (IL)-1 beta have been shown to inhibit the expression of ABCA1, while antiatherogenic cytokines, including IL-10 and transforming growth factor (TGF)-beta 1, have been shown to promote the expression of ABCA1 Moreover, some cytokines such as tumor necrosis factor (TNF)-alpha seem to regulate ABCA1 expression in species-specific and dose-dependent manners Inflammatory proteins such as C-reactive protein (CRP) and cyclooxygenase (COX)-2 are likely to inhibit ABCA1 expression during inflammation, and inflammation induced by lipopolysaccharide (LPS) was also found to block the expression of ABCA1 Interestingly, recent experiments revealed ABCA1 can function as an antiinflammatory receptor to suppress the expression of inflammatory factors, suggesting that ABCA1 may be the molecular basis for the interaction between inflammation and ROT. This review aims to summarize recent findings on the role of inflammatory cytokines, inflammatory proteins, inflammatory lipids, and the endotoxin-mediated inflammatory process in expression of ABCA1. Also covered is the current understanding of the function of ABCA1 in modulating the immune response and inflammation through its direct and indirect antiinflammatory mechanisms including lipid transport, high-density lipoprotein (HDL) formation and apoptosis. (C) 2010 The Feinstein Institute for Medical Research, www.feinsteininstitute.org
参考文献:
Abe-Dohmae S, 2006, J LIPID RES, V47, P1542, DOI 10.1194/jlr.M600145-JLR200
Aiello RJ, 2002, ARTERIOSCL THROM VAS, V22, P630, DOI 10.1161/01.ATV.0000014804.35824.DA
Aiello RJ, 2003, ARTERIOSCL THROM VAS, V23, P972, DOI 10.1161/01.ATV.0000054661.21499.FB
Anderson MM, 1999, J CLIN INVEST, V104, P103, DOI 10.1172/JCI3042
Arai S, 2005, CELL METAB, V1, P201, DOI 10.1016/j.cmet.2005.02.002

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com