Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Chi;Liu, Wengang;He, Wei;Wang, Haibin*;Chen, Qunqun;...

通讯作者：

Wang, Haibin

作者机构：

[Wang, Haibin; Chen, Qunqun; Zhou, Chi; He, Wei] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 510405, Guangdong, Peoples R China.

[Liu, Wengang] 2nd Tradit Chinese Med Hosp Guangdong Prov, Guangzhou, Guangdong, Peoples R China.

[Song, Houpan] Hunan Univ Chinese Med, Inst TCM Diagnost, Changsha 410007, Hunan, Peoples R China.

[Wang, Haibin] Guangzhou Univ Chinese Med, Affiliated Hosp 1, 16 Airport Rd, Guangzhou 510405, Guangdong, Peoples R China.

通讯机构：

[Wang, Haibin] G

Guangzhou Univ Chinese Med, Affiliated Hosp 1, 16 Airport Rd, Guangzhou 510405, Guangdong, Peoples R China.

语种：

英文

关键词：

MAPK;NF-kappaB;Osteoclast;RANKL;Saikosaponin a

期刊：

International Immunopharmacology

ISSN：

1567-5769

年：

2015

卷：

期：

页码：

49-54

DOI：

10.1016/j.intimp.2015.01.010

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81373665]; Industrial Technology Research and Development Fund of Guangdong Province [2013B021800226]

机构署名：

本校为其他机构

院系归属：

中医学院

摘要：

Inflammatory cytokines play an important role in osteoclastogenesis. Saikosaponin a (SSa) possesses anti-inflammatory activity. However, the role of SSa in osteoporosis is still unclear. Therefore, the objective of this study was to investigate the effects of SSa on receptor activator of the nuclear factor-kappa B ligand (RANKL)-induced osteoclastogenesis and signaling pathway by in vitro assay. In mouse bone marrow monocytes (BMMs), SSa suppressed RANKL plus macrophage colony-stimulating factor (M-CSF)-induced osteodast differentiation in a dose-dependent manner. Moreover, SSa decreased osteo...

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Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways

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