Pharmacokinetics and tissue distribution study of tanshinone IIA after oral administration of Bushen Huoxue Qubi granules to rats with blood stasis syndrome

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成果类型：

期刊论文

作者：

Wang, Yuanqing;Yan, Jianye;Li, Shunxiang*;Cai, Xiong（蔡雄）;Wang, Wei;...

通讯作者：

Li, Shunxiang

作者机构：

[Wang, Yuanqing; Yan, Jianye; Li, Shunxiang; Luo, Kun; Huang, Dan] Hunan Univ Chinese Med, Dept Chem, Key Lab Modernizat Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Wang, Wei] Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China.

[Cai, Xiong] Hunan Univ Chinese Med, Diagnost Inst Tradit Chinese Med, Dept Diag, Changsha 410208, Hunan, Peoples R China.

[Wang, Yuanqing] Cent South Univ Forestry & Technol, Sch Life Sci & Technol, Lab Biotechnol & Engn, Dept Biotechnol, Changsha, Hunan, Peoples R China.

[Gao, Jiesheng] Cent S Univ, Xiangya Hosp 2, Dept Rheumatism & Immunol, Changsha, Hunan, Peoples R China.

通讯机构：

[Li, Shunxiang] H

Hunan Univ Chinese Med, Sch Pharm, Key Lab Modernizat Chinese Med, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Blood stasis;Bushen Huoxue Qubi granules;high performance liquid chromatography;pharmacokinetics;tanshinone IIA;tissue distribution

期刊：

Pharmacognosy Magazine

ISSN：

0973-1296

年：

2014

卷：

期：

页码：

285-291

DOI：

10.4103/0973-1296.137369

基金类别：

Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province for Innovation of Chinese Medicine and Resources sustained utilization [2010212]; Hunan Provincial Science and Technology Department Foundation [2009TP4051-1]; Changsha Scientific Research Foundation [k1003034-31]

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

药学院

摘要：

Background: Bushen Huoxue Qubi (BHQ) granules, a traditional Chinese medicine preparation, has been clinically used for the treatment of the blood stasis syndrome. Objective: The main objective is to investigate whether the diseased condition would alter the pharmacokinetics and tissue distribution of tanshinone IIA in BHQ, which was given orally to the acute blood stasis rats. Materials and Methods: The main bioactive constituent in BHQ, tanshinone IIA, was measured in the plasma and tissues of animals by the high performance liquid chromatography with ultraviolet detection. The analysis was ...

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Pharmacokinetics and tissue distribution study of tanshinone IIA after oral administration of Bushen Huoxue Qubi granules to rats with blood stasis syndrome

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