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Oxytocin activation of neurons in ventral tegmental area and interfascicular nucleus of mouse midbrain

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成果类型:
期刊论文
作者:
Tang, Yamei;Chen, Zhiheng;Tao, Huai(陶怀);Li, Cunyan;Zhang, Xianghui;...
通讯作者:
Liu, Yong
作者机构:
[Li, Cunyan; Tang, Aiguo; Tang, Yamei] Cent S Univ, Xiangya Hosp 2, Dept Lab, Changsha 410011, Hunan, Peoples R China.
[Chen, Zhiheng] Cent S Univ, Xiangya Hosp 3, Dept Pediat, Changsha 410013, Hunan, Peoples R China.
[Tao, Huai] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha 410208, Hunan, Peoples R China.
[Zhang, Xianghui; Liu, Yong] Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China.
[Liu, Yong] Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, 139 Renmin Middle Rd, Changsha 410011, Hunan, Peoples R China.
通讯机构:
[Liu, Yong] C
Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, 139 Renmin Middle Rd, Changsha 410011, Hunan, Peoples R China.
语种:
英文
关键词:
I(h);IF;Interfascicular nucleus;NCX;NSCC;Na(+)-Ca(2+) exchanger;OT;OTR;Oxytocin;PFC;PLC;VTA;Vasopressin;Ventral tegmental area;hyperpolarization-activated current;interfascicular nucleus;nonselective cation channel;oxytocin;oxytocin receptor;phospholipase C;prefrontal cortex;ventral tegmental area
期刊:
Neuropharmacology
ISSN:
0028-3908
年:
2014
卷:
77
页码:
277-284
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81171268]
机构署名:
本校为其他机构
院系归属:
医学院
中医学院
摘要:
Oxytocin (OT) was reported to affect cognitive and emotional behavior by action in ventral tegmental area (VTA) and other brain areas. However, it is still unclear how OT activates VTA and related midline nucleus. Here, using patch-clamp recording, we studied the effects of OT on neuron activity in VTA and interfascicular nucleus (IF). OT dose-dependently and selectively excited small neurons located in medial VTA and the majority of IF neurons but not large neurons in lateral VIA. We found the hyperpolarization-activated current (I-h) and the membrane capacitance of OT-sensitive neuron were s...

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