期刊论文

中文

中国动脉硬化杂志

1007-3949

2004

12

2

215-217

10.3969/j.issn.1007-3949.2004.02.024

国家自然科学基金

本校为第一机构

探讨血管紧张素转化酶基因插入/缺失多态性与湖南汉族人冠心病之间的关系,采用聚合酶链反应检测100冠心病患者和54 例健康人的血管紧张素转化酶基因型,同时检测内皮素、血管紧张素Ⅱ和一氧化氮水平.结果发现,冠心病组血管紧张素转化酶基因型及等位基因频率与对照组相比有显著性差异(P < 0.01).与插入缺失杂合型(ID)+插入纯合型(II)相比,缺失纯合型(DD)比值比为7.27(χ~2 = 13.42,95%CI为2.38～22.24, P < 0.01). 内皮素/一氧化氮比值、血管紧张素Ⅱ水平在冠心病组明显高于对照组(P < 0.05或P < 0.01).结果提示,湖南汉族人冠心病的发生可能与DD型血管紧张素转化酶基因密切相关.

Aim To study the association between insertion /deletion (I/D) polymorphism of angiotensin converting enzyme gene and coronary heart disease (CHD) in Hunan Han population. Methods By polymerase chain reaction (PCR), 100 patients with CHD and 54 healthy people were detected for their angiotensin-converting enzyme (ACE) genotypes and allele frequencies. Angiotensin Ⅱ (Ang Ⅱ), nitric oxide (NO) and endothelins (ET) were also detected in the above people. Results The frequencies of DD genotype and allele of CHD group were marked higher than that ...