作者机构：
[Yang, Lei; Lu, Chengyin; Xiong, Hui] Hunan Univ Chinese Med, Dept Grad Sch, Changsha, Peoples R China.;[Zhang, Hailong; Zhang, Laifu; Wang, Xiaohui; Lu, Chengyin] Luoyang Orthoped Traumatol Hosp Henan Prov, Dept Sports Med, Henan Prov Orthoped Hosp, Luoyang 471000, Peoples R China.;[Wang, Pengtao; Dong, Jiahe] Henan Univ Chinese Med, Dept Grad Sch, Zhengzhou, Peoples R China.
通讯机构：
[Xiaohui Wang MD; Hui Xiong MD] D;Department of Graduate School, Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Department of Sports Medicine, Luoyang Orthopedic-Traumatological Hospital of Henan Province (Henan Provincial Orthopedic Hospital), Luoyang, China
摘要：
Wrist arthroscopy combined with oblique ulnar shortening osteotomy in the treatment of ulnar impaction syndrome can restore the positive ulnar variation while repairing soft tissue damage such as TFCC, which can better relieve the pain of patients, improve the rate of excellent and good, and increase the satisfaction of treatment. Objective To explore the clinical effects of wrist arthroscopy combined with oblique ulnar shortening osteotomy in the treatment of ulnar impaction syndrome. Methods This was a retrospective study of 60 patients with ulnar impaction syndrome who were admitted to our department from January 2016 to December 2019. According to different surgical methods, they were divided into an observation group and a control group, with 30 cases in each group. The control group was treated with oblique ulnar shortening osteotomy, and the observation group used wrist arthroscopy based on the control group. The two groups of patients were compared in terms of wrist function before and 12 months after surgery. We compared the Disabilities of the Arm, Shoulder, and Hand Score (DASH Score), Patient‐Rated Wrist Evaluation Score (PRWE Score), Visual Analog Score (VAS), and ulnar variation between the two groups at 12 months after surgery. The excellent and good rates by Mayo wrist score were compared between the two groups at the last follow‐up. Results All patients were followed up for 12–36 months, with an average of 14.5 months. Bone union was achieved at the oblique osteotomy of the ulna, with an average healing time of 13.6 weeks. The observation group was examined by wrist arthroscopy, and the triangular fibrocartilage complex (TFCC) Palmer classification was confirmed in three cases of type IIA, seven cases of type IIB, 14 cases of type IIC, and six cases of type IID. Compared with before surgery, the grip strength, flexion‐extension, ulnar radial deflection, and forearm rotation of the two groups of patients were significantly improved at 12 months after surgery. The DASH score, PRWE score, and VAS score of the observation group were better than those of the control group, and the difference in ulnar shortening length was not statistically significant between the two groups. The excellent and good rates of the observation group (93.3%) were better than those of the control group (87.5%) at the last follow‐up, and the difference was statistically significant. Conclusion Compared with oblique ulnar shortening osteotomy alone, combined wrist arthroscopy can better reduce the pain of patients with ulnar impaction syndrome, restore wrist function, and improve the excellent and good rates. Therefore, it is clinically worthy of promotion.
通讯机构：
[Weihua Wu; Kai He] H;Hunan Provincial Key Laboratory of Dong Medicine, Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Science, Hunan University of Medicine, Huaihua, 418000, Hunan, China<&wdkj&>Hunan Provincial Key Laboratory of Dong Medicine, Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Science, Hunan University of Medicine, Huaihua, 418000, Hunan, China
关键词：
Bidirectional effects;Blood circulation;Central nervous system;Gastrointestinal motility;Immune function;Traditional Chinese medicine
摘要：
ETHNOPHARMACOLOGICAL RELEVANCE: The bidirectional property of traditional Chinese medicines (TCMs) was recorded in the classic work Medicine Origin (Yi Xue Qi Yuan) as early as the Jin and Yuan dynasties of ancient China. Since then, this imperative theory has been applied to guide the clinical application of TCMs. Studies have been performed to investigate this phenomenon only over the last three decades. A limited number of reviews on the bidirectional role of TCMs have been published, and almost all current studies are published in the Chinese language. AIM OF THE REVIEW: The aim of this review is to provide the first comprehensive evidence regarding the bidirectional effects and the underlying mechanisms of TCMs and their active compounds. MATERIALS AND METHODS: Information relevant to opposing pharmacological activities or opposing properties exerted by TCM prescriptions, herbal medicines, and their active compound, as well as their mechanisms was summarized by searching Chinese and English databases, including the Chinese National Knowledge Infrastructure (CNKI), Wan Fang Data, Chinese Scientific Journal Database (VIP), Google Scholar, PubMed, Web of Science, Science Direct, and Wiley Online Library. RESULTS: Although the bidirectional regulation of TCMs has been applied in the clinic since ancient times in China, only limited reviews have been published in Chinese. The existing data showed that bidirectional effects can be found in TCM prescriptions, herbal medicines, and pure active compounds. Additionally, the bidirectional role of TCMs was primarily reported in the modulation of immune function, blood circulation and hemostasis, gastrointestinal motility, the central nervous system and blood pressure. This may because the therapeutic outcomes of these disorders are more obvious than those of other complicated diseases. Intriguingly, some herbal medicines have multiple bidirectional activities; for instance, Panax ginseng C. A. Meyer showed bidirectional regulation of immune function and the central nervous system; Astragalus membranaceus can bidirectionally regulate blood pressure and immune function; and Rheum officinale Baill exerts bidirectional effects on blood circulation and hemostasis, gastrointestinal motility and immune function. The mechanisms underlying the bidirectional effects of TCMs are largely attributed to the complexity of herbal constituents, dosage differences, the processing of herbal medicine, and compatibility of medicines, the physiological conditions of patients and adaptogenic effects. CONCLUSION: Uncovering the bidirectional effects and mechanisms of TCMs is of great importance for both scientific research and clinical applications. This review may help to facilitate the recognition of the bidirectional role of TCMs, to explain some seemingly-opposite phenomena in the pharmacological study of herbal medicines and to provide guidance for TCM practitioners.
作者机构：
[Hu, Kuan; Yao, Lei] Cent South Univ, Xiangya Hosp, Dept Hepatobiliary Surg, Changsha 410008, Hunan, Peoples R China.;[Li, Juanni] Cent South Univ, Xiangya Hosp, Dept Pathol, Changsha, Peoples R China.;[Li, Juanni] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.;[Zhang, Xiaofang] Hunan Univ Chinese Med, Ningxiang Peoples Hosp, Dept Burn, Changsha, Peoples R China.;[Zhang, Xiaofang] Hunan Univ Chinese Med, Ningxiang Peoples Hosp, Dept Plast, Changsha, Peoples R China.
通讯机构：
[Kuan Hu] D;Department of Hepatobiliary Surgery, Xiangya Hospital, Central South University, Changsha, China
关键词：
chemoresistance;ferroptosis;GBM;SQLE;TMZ
摘要：
Chemoresistance in patients with glioblastoma multiforme (GBM) is a common reason hindering the success of treatment. Recently, ferroptosis has been reported to be associated with chemoresistance in different types of cancer, while the role of ferroptosis-related genes in GBM have not been fully elucidated. This study aimed to demonstrate the roles and mechanism of ferroptosis-related genes in chemoresistance and metastasis of GBM. First, two candidate genes, squalene epoxidase (SQLE) and FANCD2, were identified to be associated with ferroptosis-related chemoresistance in GBM from three temozolomide (TMZ) therapeutic datasets and one ferroptosis-related gene dataset. Then, comprehensive bio-informatics data from different databases testified that SQLE was significantly downregulated both in GBM tissue and cells and displayed a better prognosis in GBM. Clinical data identified lower expression of SQLE was significantly associated with WHO grade and 1p/19q codeletion. Moreover, through in vitro experiments, SQLE was confirmed to suppress ERK-mediated TMZ chemoresistance and metastasis of GBM cells. The KEGG analysis of SQLE-associated co-expressed genes indicated SQLE was potentially involved in the cell cycle. Furthermore, SQLE was found to have the most significant correlations with tumor-infiltrating lymphocytes and immunomodulators. These findings highlighted that SQLE could be a potential target and a biomarker for therapy and prognosis of patients with GBM.
摘要：
Exploration of new drugs targeting anxiety treatment is a major concern worldwide. Medicinal plants are being used as a potential source of novel drugs for anxiety disorders. The objective of this review is to provide information about the healing outcomes of anxiety treatment with natural products. Valeriana officinalis, Citrus aurantium, Commelina benghalensis, Achyranthes aspera, Mimosa pudica, Achillea millefolium, Nymphaea alba, Leonurus cardiac, Camellia sinensis, Turnera aphrodisiaca, Crataegus oxyacantha and Piper methysticum showed promising effects on anxiety in animal models. In clinical studies, passion flower, kava, valerian, St John's wort, and hwagandha showed the most positive results. More studies are needed for the exploration of the antianxiety of medicinal plants. In drugs derived from natural sources have explored many components that are playing an essential role in curing anxiety disorders and associated complications.
摘要：
Journal of Orthopaedic Surgery, Volume 30, Issue 3, September-December 2022. <br/>PurposeThis study aims to explore the potential mechanism of Achyranthoside D (AD) in improving intervertebral disc (IVD) degeneration (IDD).MethodsThe IDD model of SD rats and nucleus pulposus cells (NPCs) was established by lumbar cone annulus puncture and tert-butyl peroxide, respectively. Cell proliferation was detected by CCK8 assay. Apoptosis was detected by flow cytometry and TUNEL staining. IVD tissue injury was observed by HE staining. Alcian blue staining observed the glycoprotein secretion in IVD. Monodansylcadaverin (MDC) staining was used to detect the formation of autophagosomes. The LC3 expression was tested by immunofluorescence. The type II collagen, aggrecan and MMP3 expression were detected by ELISA. RT-qPCR was used to detect the Casp 3, Bax, Bcl2, Acan, Col2a1 and Mmp3 expression. The LC3, P62, type II collagen, aggrecan, Beclin1, Akt, MMP3, p-mTOR, PI3K, mTOR, p-PI3K and p-Akt expression were analyzed by western blot.ResultsThe IVD tissue damage and apoptosis occurred in the Model group, and the glycoprotein secretion decreased. Compared with Model group, AD-H group alleviated the injury of IVD tissue, inhibited the apoptosis of cells, and increased the secretion of glycoprotein. 40 μg/mL AD restored the proliferation activity of NPCs. Compared to the Normal group, the NPCs apoptosis increased, the Collagen II, aggrecan and Bcl2 expressions were significantly decreased, the MMP3, Bax and Casp 3 expression were significantly increased, and the LC-3 II/I expression in IVD tissues were increased significantly in Model group, all of which was reversed in AD group. AD promoted the p-Akt, p-PI3K, p-mTOR, LC-3 II/I and Beclin1 expression, inhibited the P62 expression to alleviate the damage of nucleus pulporeus cells and the degeneration of IVD.ConclusionAD improved IDD by affecting the PI3K/Akt/mTOR pathway and autophagy.
期刊：
FRONTIERS IN AGING NEUROSCIENCE,2022年14:1019088 ISSN：1663-4365
通讯作者：
Wu, D.
作者机构：
[Wu, Dahua; Xie, Yao; Xie, Le; Yao, Ting; Fan, Jianhu; Jiang, Junlin] Hunan Acad Tradit Chinese Med Affiliated Hosp, Dept Neurol, Changsha, Peoples R China.;[Kang, Fuliang] Hunan Acad Tradit Chinese Med Affiliated Hosp, Dept Imaging, Changsha, Peoples R China.;[Mao, Guo] Hunan Acad Tradit Chinese Med Affiliated Hosp, Off Acad Res, Changsha, Peoples R China.;[Fang, Rui] Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Changsha, Peoples R China.
期刊：
Journal of Pharmacological Sciences,2022年149(3):173-173 ISSN：1347-8613
通讯作者：
Hua-An Cai<&wdkj&>Ming-Sheng Zhang
作者机构：
[Huang, Liang; Zhang, Ming-Sheng] Southern Med Univ, Clin Med Coll 2, 1838 Guangzhou Ave North, Guangzhou 510515, Guangdong, Peoples R China.;[Huang, Liang; Zhang, Ming-Sheng] Guangdong Prov Peoples Hosp, Dept Rehabil, 1838 Guangzhou Ave North, Guangzhou 510515, Guangdong, Peoples R China.;[Cai, Hua-An; Hu, Feng-Dan] Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Dept Rehabil Med, Changsha 410016, Hunan, Peoples R China.;[Cai, Hua-An] Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Dept Sports Med,Inst Translat Med, Changsha 410016, Hunan, Peoples R China.;[Liao, Ruo-Yi] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Changsha 410004, Hunan, Peoples R China.
通讯机构：
[Hua-An Cai] D;[Ming-Sheng Zhang] S;Department of Rehabilitation Medicine, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410016, Hunan Province, PR China<&wdkj&>Department of Sports Medicine, Institute of Translational Medicine, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410016, Hunan Province, PR China<&wdkj&>Second Clinical Medical College, Southern Medical University, Guangzhou, 510515, Guangdong Province, PR China<&wdkj&>Department of Rehabilitation, Guangdong Provincial People's Hospital, Guangzhou, 510515, Guangdong Province, PR China
摘要：
BACKGROUND: Alzheimer disease (AD) is a common cause of dementia, and there are still a lack of treatment options to reverse or prevent disease progression. Existing evidence shows that acupuncture has advantages in the treatment of AD, but whether the efficacy of acupuncture belongs to the placebo effect remains controversial, and there is no strict systematic review and network meta-analysis to evaluate the efficacy and safety of acupuncture combined with Western medicine in the treatment of AD. METHODS: From the inception to February 2023, the Embase, Latin American and Caribbean Health Sciences Literature, Medline, the Cochrane Collaboration's Controlled Clinical Trials, Scopus, China Biomedical Literature Database, Wanfang Database, China National Knowledge Infrastructure, and Australian Medical Index will be searched using the key phrases "acupuncture," "warm needling," "electroacupuncture," "Alzheimer disease," and "cohort" for all relevant studies. Quality assessment of all studies included in this review will be independently assessed by 2 reviewers using the Cochrane Collaborations tool. When significant heterogeneity is indicated, we will find the source of heterogeneity by subgroup or sensitivity analysis. DISCUSSION: This study will evaluate the efficacy of acupuncture combined with Western medicine in improving cognitive function and activities of daily living in AD patients. The results of this study will verify whether the efficacy of acupuncture in the treatment of AD belongs to the placebo effect, which will also provide a reference for the clinical use of acupuncture combined with Western medicine in the treatment of AD.
作者机构：
[Ding, Ning; Wang, Huashuai] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.;[Yao, Jia; Wang, Huashuai] Hunan Acad Tradit Chinese Med, Affiliated Hosp, Dept Anorectal Surg, Changsha 410006, Hunan, Peoples R China.;[Yao, Jia; He, Yongheng] Guangzhou Univ Chinese Med, Sch Clin Med 2, Guangzhou, Peoples R China.;[Yao, Jia] Guangdong Prov Hosp Chinese Med, Dept Endocrinol, Guangzhou, Peoples R China.
关键词：
body mass index;cross-sectional study;NHANES;uric acid
摘要：
Clinical investigation of obesity-related risk factors aids in the early detection, prevention, and management of obesity. We aimed to examine the association between obesity and serum uric acid (sUA). A cross-sectional study was conducted including 18473 subjects from the National Health and Nutrition Examination Survey (NHANES). The exposure and outcome variables were sUA and body mass index (BMI), respectively. The weighted multivariate linear regression models and smooth curve fittings were conducted to assess the association between sUA and BMI. There were significantly positive correlations between sUA and BMI in both males and females (beta = 1.414, 95% CI: 1.323-1.505, P < .0001, beta = 1.853, 95% CI: 1.740-1.966, P < .0001, respectively). Furthermore, individuals in the higher sUA quartiles had higher BMI than those in the lowest quartile in both males and females. Subgroup analyses were stratified by race/ethnicity, results indicated the positive association of sUA with BMI in males remained in all races including Mexican American (beta = 1.203, 95% CI: 0.965-1.442, P < .0001), other Hispanic (beta = 1.126, 95% CI: 0.858-1.395, P < .0001), non-Hispanic White (beta = 1.493, 95% CI: 1.343-1.642, P < .0001), non-Hispanic Black (beta = 1.331, 95% CI: 1.122-1.540, P < .0001), and other races (beta = 1.329, 95% CI: 1.115-1.544, P < .0001). And the positive association of sUA with BMI in females also remained in all races including Mexican American (beta = 1.806, 95% CI: 1.520-2.092, P < .0001), other Hispanic (beta = 2.033, 95% CI: 1.687-2.379, P < .0001), non-Hispanic White (beta = 1.847, 95% CI: 1.657-2.037, P < .0001), non-Hispanic Black (beta = 2.141, 95% CI: 1.874-2.408, P < .0001), and other races (beta = 1.348, 95% CI: 1.081-1.615, P < .0001). The current cross-sectional study with 18473 US participants found that an elevated sUA was positively correlated with a higher BMI in males, females, and all kinds of races.
摘要：
BACKGROUND Ovarian cancer has the highest mortality of gynecological cancers worldwide. The aim of this study was to identify the role of tripterine against ovarian cancer. MATERIAL AND METHODS GSE18520 and GSE12470 data sets were downloaded from the GEO database. WGCNA was used to analyze gene modules and hub genes related to ovarian cancer. These hub genes were intersected with tripterine targets, and GO and KEGG enrichment analyses were performed. HPA and GEPIA determined the expression of tripterine anti-ovarian hub genes in tumor tissues. Kaplan-Meier plotter was used to explore the role of hub genes in ovarian cancer prognosis. AutoDock was used to conduct molecular docking of tripterine and hub genes to observe whether the combination was stable. RESULTS By differential analysis of gene expression and the construction of WGCNA co-expression network, 5 hub genes, ARHGAP11A, MUC1, HBB, RUNX1T1, and FUT8, were screened by module gene screening. Seven biological processes and 20 KEGG-related pathways were obtained by gene enrichment. The expression of tripterine anti-ovarian hub genes ARHGAP11A, MUC1, and FUT8 were obtained by HPA and GEPIA. Using Kaplan-Meier plotter, the survival of ovarian cancer was negatively correlated with ARHGAP11A, MUC1, and FUT8. Molecular docking showed the combination of tripterine and FUT8 was most stable, having the greatest potential role. CONCLUSIONS Tripterine may be involved in megakaryocyte development and platelet production through potential genes ARHGAP11A, MUC1, HBB, RUNX1T1, and FUT8 and may have an anti-ovarian cancer effect in immune factors signaling, transporting and exchanging oxygen pathways, and autophagy pathways, through these 5 key genes.
作者机构：
[Li, Bin; Wang, Wei; Sheng, Wen-Bing; Xie, Qing-Ling; Liu, Xin-Yi; Zhou, Xu-Dong; Cui, Pei-Wu; Gong, Li-Min; Tang, Hong-Xia] Hunan Univ Chinese Med, Sch Pharm, Innovat Mat Med Res Inst, TCM & Ethnomed Innovat & Dev Int Lab, Changsha, Peoples R China.;[Wang, Wen-Mao] Hunan Qiankun Biotechnol Co Ltd, Meicha Technol Res Ctr, Zhangjiajie, Hunan, Peoples R China.
通讯机构：
[Wei Wang; Xu-Dong Zhou] T;TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, P.R. China<&wdkj&>TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, P.R. China
作者机构：
[Xu, Ying; Ge, Jin-wen; Zhong, Da-yuan; Liao, Xiao-qian] Hunan Univ Tradit Chinese Med, Changsha 410208, Peoples R China.;[Xu, Wei-hui; Xu, Ying] Hunan Univ Tradit Chinese Med, Hosp 3, Zhuzhou 412000, Peoples R China.;[Wang, Xing-ping] Beijing Univ Chinese Med, Beijing 102488, Peoples R China.
关键词：
Acupuncture;AMSTAR-2;GRADE;review;stroke
摘要：
Objective: This systematic review (SR) of SRs aims aimed to evaluate the current evidence of rehabilitation interventions in stroke patients after acupuncture treatment. Methods: Full-text SRs published in Chinese and English up to December 15, 2021 were searched in PubMed, Embase, Cochrane Library, CNKI, VIP, and Wanfang databases. The PRISMA statement and the assessment of multiple systematic reviews 2 (AMSTAR 2) scale were used to evaluate the quality of the included articles. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system was employed to assess the outcome indicators for evidence quality evaluation. Results: A number of 42 publications were identified in this study. According to these articles, 4 metabolic areas were identified: systolic blood pressure, weight loss, glycemic index and cholesterol. The acupuncture is beneficial to improve the systolic blood pressure of patients, and the effect of acupuncture on diastolic blood pressure is better than that of sham acupuncture. The weight loss effect of acupuncture is better than that of lifestyle and western medicine. The improvement effect of acupuncture on body mass index (BMI) is also better than that of sham acupuncture. In the study of glycemic index of stroke patients, acupuncture significantly improved glycosylated hemoglobin and insulin sensitivity index compared with western medicine. In cholesterol-related research, acupuncture can effectively improve the content of triglycerides. However, studies on HDL and LDL show that acupuncture can significantly improve HDL, but has no significant effect on LDL. Conclusion: This review summarizes the available evidence and underpins findings of the acupuncture exhibited the therapeutic role in eliminating metabolic risk factors for stroke, including systolic blood pressure, weight loss, glycemic index and cholesterol. Acupuncture could have positive effects on a specific symptom, and the effects depend not only on intervention type but also on how and when the intervention is provided. And more prioritizing high-quality research in this field in the future is conducive to guiding clinical practice.
期刊：
International Journal of Biological Macromolecules,2022年203:176-183 ISSN：0141-8130
通讯作者：
Peng, YB;Huang, XK
作者机构：
[Zeng, Yajun; Peng, Yongbo; Peng, Qiyao; Peng, YB; Wang, Junyi; Yu, Chao] Chongqing Med Univ, Coll Pharm, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China.;[Peng, Yongbo; Zhou, Rongrong; Wan, Dan; Peng, Qiyao; Zhang, Shuihan] Hunan Acad Tradit Chinese Med, Inst Chinese Med, Changsha 410208, Peoples R China.;[Peng, Yongbo; Zhou, Rongrong; Wan, Dan; Peng, Qiyao; Zhang, Shuihan] Hunan Univ Chinese Med, Changsha 410208, Peoples R China.;[Huang, XK; Huang, Xuekuan; Luo, Hongyu] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing Key Lab Tradit Chinese Med Prevent & Cu, Chongqing 410016, Peoples R China.;[Ren, Lingyan] Chongqing Univ Sci & Technol, Sch Safety Engn, Chongqing 401331, Peoples R China.
通讯机构：
[Peng, YB ; Huang, XK ] C;Chongqing Med Univ, Coll Pharm, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China.;Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing Key Lab Tradit Chinese Med Prevent & Cu, Chongqing 410016, Peoples R China.
关键词：
Function and structure;INO80;NFRKB
摘要：
The INO80 chromatin remodeling complex plays an essential role in the regulation of gene transcription, which participate in a variety of important biological processes in cells including DNA repair and DNA replication. Difference from the yeast INO80 complex, metazoan INO80 complex have the specific subunit G, which is known as nuclear factor related to kappaB binding protein (NFRKB). Recently, NFRKB has been received much attention in many aspects, such as DNA repair, cell pluripotency, telomere protection, and protein activity regulation. To dig the new function of metazoan INO80 complex, a better understanding of the role of NFRKB is required. In this review, we provide an overview of the structure and function of NFRKB and discuss its potential role in cancer treatment and telomere regulation. Overall, this review provides an important reference for further research of the INO80 complex and NFRKB.
作者机构：
[Tian, Xue-fei; Zhang, Zhen] Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Dept Internal Med, Changsha 410208, Peoples R China.;[Tian, Xue-fei; Zhang, Zhen; Gao, Wen-hui] Hunan Univ Chinese Med, Hunan Key Lab TCM Prescript & Syndromes Translat, Changsha 410208, Peoples R China.;[Li, Jun-wei] Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Pharm, Shenzhen 518020, Guangdong, Peoples R China.;[Li, Jun-wei] Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China.;[Zeng, Pu-hua] Hunan Acad Tradit Chinese Med, Affiliated Hosp, Dept Oncol, Changsha 410006, Peoples R China.
通讯机构：
[Xue-fei Tian] D;Department of Internal Medicine, College of Integrated Chinese and Western Medicine of Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Hunan Key Laboratory of TCM Prescription and Syndromes Translational Medicine, Hunan University of Chinese Medicine, Changsha, China
关键词：
Chinese medicine;primary liver cancer;system pharmacology;bioinformatics;tumor microenvironment
通讯机构：
[Weihong Jiang] D;Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, People’s Republic of China<&wdkj&>Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha, People’s Republic of China<&wdkj&>National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People’s Republic of China
摘要：
PURPOSE: Subcutaneous immunotherapy (SCIT) is an effective treatment for pediatric allergic rhinitis (AR), but its efficacy fluctuates among individuals. This study aims to identify the profile of serum exosomes derived microRNAs (miRNAs) and evaluate their capacities to early predict SCIT efficacy in pediatric AR. PATIENTS AND METHODS: High-throughput sequencing was applied to identify the miRNA of serum exosomes in AR children. GO enrichment and KEGG pathway analysis were performed to enrich the biological annotations of target mRNAs of miRNAs. Then we validated differentially expressed miRNAs in two independent cohorts by RT-qPCR. Logistic regression and receiver operating characteristic curve (ROC) were applied to evaluate the abilities of identified miRNAs in predicting the efficacy of SCIT in AR children. RESULTS: A total of 812 miRNAs were detected in the serum exosomes, including 16 upregulated and 14 downregulated. Differentially expressed genes are enriched in the biological process of developmental process and regulation of cellular process, and gathered in pathways such as the signaling pathways regulating pluripotency of stem cells and the Wnt signaling pathway. In the first validation cohort, hsa-miR-4669 (P=0.009) and hsa-miR-4686 (P=0.032) were significantly downregulated in the effective group than the ineffective group, while hsa-miR-3196 (P=0.015) was upregulated. In the second cohort, hsa-miR-4669 level (P<0.0001) was downregulated in the effective group than the ineffective group. In addition, logistic regression revealed that hsa-miR-4669 level was correlated with the visual analogue scale (r=0.323, P=0.001) and total nasal symptoms score (r=0.269, P =0.007). ROC curve highlighted that hsa-miR-4669 level exhibited a reliable accuracy in predicting SCIT efficacy in pediatric AR (AUC=0.785). CONCLUSION: Serum exosomes derived miRNA were associated with the efficacy of SCIT. Serum exosomes derived hsa-miR-4669 might serve as a novel biomarker for early predicting the response of SCIT in AR children.
摘要：
Long-term glycemic fluctuation has been associated with cardiovascular risk in
patients with type 2 diabetes mellitus (T2DM). However, the findings are
inconsistent. We performed a meta-analysis to summarize the association between
parameters of long-term glycemic variability and risk of cardiovascular events
in T2DM patients. Medline, Embase, and Web of Science databases were searched
for longitudinal follow-up studies comparing the incidence of cardiovascular
events in T2DM patients with higher or lower long-term glycemic variability. A
random-effect model incorporating the potential heterogeneity among the included
studies was used to pool the results. Twelve follow-up studies with 146 653 T2DM
patients were included. The mean follow-up duration was 4.9 years. Pooled
results showed that compared to those with the lowest glycemic variability,
patients with the highest glycemic variability had significantly increased risk
of cardiovascular events, as evidenced by the standard deviation of glycated
hemoglobin [HbA1c-SD: relative risk (RR)=1.44, 95% confidence
interval (CI): 1.23 to 1.69, p<0.001;
I2=70%], HbA1c coefficient of variation (HbA1c-CV:
RR=1.46, 95% CI: 1.19 to 1.79. p<0.001;
I2=83%), standard deviation of fasting plasma glucose
(FPG-SD: RR=1.33, 95% CI: 1.07 to 1.65, p=0.009;
I2=0%), and FPG coefficient of variation (FPG-CV:
RR=1.29, 95% CI: 1.01 to 1.64, p=0.04;
I2=47%). In conclusion, increased long-term glycemic
variability may be an independent risk factor for cardiovascular events in T2DM
patients.
