期刊:
Transactions on Emerging Telecommunications Technologies,2022年33(5) ISSN:2161-3915
通讯作者:
Ming, Zhao
作者机构:
[Li, Ting; Ming, Zhao] Cent South Univ, Sch Comp Sci & Engn, Changsha, Peoples R China.;[Liu, Wei] Hunan Univ Chinese Med, Sch Informat, Changsha, Peoples R China.;[Wang, Tian] Huaqiao Univ, Coll Comp Sci & Technol, Xiamen, Peoples R China.;[Li, Xiong] Hunan Univ Sci & Technol, Sch Comp Sci & Engn, Xiangtan, Peoples R China.;[Ma, Ming] SUNY Stony Brook, Dept Comp Sci, Stony Brook, NY 11794 USA.
通讯机构:
[Ming, Zhao] C;Cent South Univ, Sch Comp Sci & Engn, Changsha, Peoples R China.
摘要:
Due to their mobile character, ground vehicles and unmanned aerial vehicles (UAVs) are currently being considered as sensing devices that can collect data in the Internet of Things (IoT). Building and enhancing trust and security environments in data collection processes are fundamental and essential requirements. Here, we proposed a novel scheme named “Trust Data Collections via Vehicles joint with UAVs in the Smart Internet of Things” (T-SIoTs scheme), which targets to establish a trust-based environment for data collections by utilizing both trust vehicles and UAVs. First, to optimize security aspect, data center (DC) selected trust-based vehicles as mobile data collectors via analyzing and digging historical datasets. To promise coverage regions of data collections, several static stations are established, which can be utilized as static data collectors. Second, UAVs are arranged by the DC to collect data stored by both trust-based vehicles and static data collectors. In the T-SIoTs scheme, trajectories of UAVs are designed according to shortest-distance-first routing scheme. Comprehensive theoretical analyses and experiments have been provided to evaluate and support the T-SIoTs scheme. Compared with the previous studies, the T-SIoTs scheme can improve the security ratio by 46.133% to 54.60% approximately. And with the routing scheme, the energy consumptions of UAVs can be reduced by 46.93% approximately.
期刊:
Transactions on Emerging Telecommunications Technologies,2021年32(6) ISSN:2161-3915
通讯作者:
Liu, Anfeng
作者机构:
[Tan, Jiawei; Zhao, Ming; Liu, Anfeng] Cent S Univ, Sch Comp Sci & Engn, Changsha 410083, Peoples R China.;[Liu, Wei] Hunan Univ Chinese Med, Sch Informat, Changsha, Peoples R China.;[Wang, Tian] Huaqiao Univ, Coll Comp Sci & Technol, Xiamen, Peoples R China.;[Zhang, Shaobo] Hunan Univ Sci & Technol, Sch Comp Sci & Engn, Xiangtan, Peoples R China.
通讯机构:
[Liu, Anfeng] C;Cent S Univ, Sch Comp Sci & Engn, Changsha 410083, Peoples R China.
摘要:
Mobile edge computing (MEC) is envisioned as a promising platform for supporting emerging computation-intensive applications on capacity and resource constrained mobile devices (MDs). In this platform, the task with high computing resource demand can be offloaded to edge nodes for computing. Moreover, the computing result can be cached to edge nodes. When other MDs request the task that has been cached, the edge nodes can directly return the result to MD. However, the storage capacity of edge nodes is limited, the effective task prediction and caching scheme is one of the key issues for MEC. In this article, a matrix completion technology based content popularity prediction joint cache placement (MCTCPP-CP) scheme is proposed to tackle this issue for MEC. On the one hand, the MCTCPP-CP scheme is the first scheme using matrix completion (MC) technology to content popularity prediction. It proved by experiments that the accuracy of using MC technology to estimate caching content is improved compared with the previous methods. On the other hand, a cache placement decision approach based on the benefit of unit storage is proposed. Extensive numerical studies demonstrate the superior performance of our MCTCPP-CP scheme. The key performance indicators such as task duration, hit rate, estimated error are better than previous schemes by about: 0.13% to 14.01%, 17.28% to 37.65%, and 8.17%.
摘要:
A highly reactive hollow tubular g-C3N4 isotype heterojunction (SCN-CN) was designed to enhance visible light absorption and manipulate the directed transfer of electrons and holes. The results of UV-vis DRS, XPS valence band and DFT theoretical calculations indicated S doping increases the visible-light absorption capacity and changed the ba nd gap structure of g-C3N4 (CN), resulting in the transfer of electrons from the CN to the SCN and holes from the SCN to the CN under visible light. In addition, the tubular structure of the SCN-CN facilitated the transfer of electrons in the longitudinal direction, which reduced charge carrier recombination. Furthermore, the optical properties, electronic structure, and electron transfer of SCN-CN were also studied by experiments and theoretical calculations. The antibiotic tetracycline hydrochloride (TCH) and dye Rhodamine B (RHB) were subjected to evaluate the photocatalytic performance of SCN-CN. The scavenger tests and ESR data showed that the h(+), center dot O-2(-) and center dot OH worked together in the photocatalytic process. Moreover, the photocatalytic degradation pathway was analyzed by LC-MS. This study synthesized a hollow tubular CN isotype heterojunction with high visible-light photocatalytic performance and provided a theoretical basis for CN isotype heterojunction. Graphical abstract
摘要:
Photocatalysis is an efficient technology for energy production and environmental remediation. The composites of metal organic frameworks (MOFs) combined with quantum dots (QDs) allow high photocatalytic ability. Recently, these composites have been applied increasingly in the fields of energy production and environmental remediation. Even so, QD-MOF composites still have some shortcomings in the field of photocatalysis. In this review, the synthesis methods and structures as well as the applications of QD-MOF composites in water splitting for hydrogen production, carbon dioxide (CO2) reduction to produce methane (CH4), organic dye degradation, Cr(VI) reduction, and nitric oxide (NO) oxidation are discussed. The mechanisms of these processes are also described in detail. Finally, new insights into the future development and challenges of the composite are proposed to advance further development of the research area. (C) 2019 Elsevier B.V. All rights reserved.
作者机构:
[Liu, Yanfei; Hu, Yaqin; Wen, Nachuan; Wang, Ying] Cent S Univ, Coll Chem & Chem Engn, Dept Pharmaceut Engn, Changsha 410083, Hunan, Peoples R China.;[Liu, Zhenbao; Cai, Shundong; He, Qunye; Yan, Jianhua; Xiong, Hongjie] Cent S Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmaceut, Changsha 410013, Hunan, Peoples R China.;[Peng, Dongming] Hunan Univ Chinese Med, Sch Pharm, Dept Med Chem, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Liu, Yanfei; Liu, Zhenbao] C;Cent S Univ, Coll Chem & Chem Engn, Dept Pharmaceut Engn, Changsha 410083, Hunan, Peoples R China.;Cent S Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmaceut, Changsha 410013, Hunan, Peoples R China.
关键词:
Drug delivery system;Drug release mechanism;Metal-organic framework;Stimuli-responsive
摘要:
Metal-organic framework (MOF), a novel hybrid porous material which is composited by metal ions and organic linkers, has drawn increasing attention and became a promising material in the biomedical field owing to their unique properties including large pore volume, high surface area, tunable pore size, versatile functionality and high drug loading efficiency. However, the MOF families and members, and the drug release mechanisms in MOF-based stimuli-responsive drug delivery systems (DDSs) are rarely summarized. Here, we systematically classified the families of MOF and introduced some representative members in MOF families. Moreover, the underlying drug release mechanisms were interpreted according to endogenous stimuli (include pH, glutathione (GSH), adenosine-triphosphate (ATP), ion, glucose, enzyme, H2S, and etc.) and the exogenous stimuli (include light, temperature, pressure, and etc.). Furthermore, the remaining challenges and future directions of DDSs based on MOF are discussed and proposed. This review revealed the relationship between the structure and properties of MOF. A better understanding of these release mechanisms under different stimuli would benefit the designing of sophisticated DDSs based on the promising material of MOF.
期刊:
Journal of the American Chemical Society,2019年141(2):1126-1134 ISSN:0002-7863
通讯作者:
Feng, Lei;Ma, Xiaochi
作者机构:
[Yu, Zhenlong; Tian, Xiangge; Dong, Peipei; Sun, Chengpeng; Ning, Jing; Wang, Bo; Huo, Xiaokui; Wang, Chao; Feng, Lei; Ma, Xiaochi; Shi, Lei] Dalian Med Univ, Coll Pharm, Natl & Local Joint Engn Res Ctr Drug Dev Neurodeg, Coll Integrat Med, Dalian 116044, Peoples R China.;[Ning, Jing; Liu, Tao; Cui, Jingnan; Feng, Lei] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China.;[Wang, Wei] Hunan Univ Chinese Med, Sch Pharm, Sino Pakistan TCM & Ethnomed Res Ctr 8, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China.;[Ge, Guangbo] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai 201203, Peoples R China.;[James, Tony D.] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England.
通讯机构:
[Feng, L; Ma, XC; Feng, Lei] D;Dalian Med Univ, Coll Pharm, Natl & Local Joint Engn Res Ctr Drug Dev Neurodeg, Coll Integrat Med, Dalian 116044, Peoples R China.;Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China.
作者机构:
[Yuan, Ning; Liu, Chunyu] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China.;[Yuan, Ning; Liu, Chunyu] Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China.;[Yuan, Ning; Liu, Chunyu] Cent South Univ, Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China.;[Yuan, Ning; Liu, Chunyu] Cent South Univ, Natl Technol Inst Mental Disorders, Changsha, Hunan, Peoples R China.;[Yuan, Ning; Liu, Chunyu] Hunan Univ Chinese Med, Sch Clin Med, Hunan Prov Brain Hosp, Dept Psychiat, Changsha, Hunan, Peoples R China.
通讯机构:
[Liu, Chunyu] C;[Liu, Chunyu] H;Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China.;Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China.;Cent South Univ, Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China.
摘要:
Inflammation is a natural defence response of the immune system against environmental insult, stress and injury, but hyper- and hypo-inflammatory responses can trigger diseases. Accumulating evidence suggests that inflammation is involved in multiple psychiatric disorders. Using inflammation-related factors as biomarkers of psychiatric disorders requires the proof of reproducibility and specificity of the changes in different disorders, which remains to be established. We performed a cross-disorder study by systematically evaluating the meta-analysis results of inflammation-related factors in eight major psychiatric disorders, including schizophrenia (SCZ), bipolar disorder (BD), autism spectrum disorder (ASD), major depression disorder (MDD), post-trauma stress disorder (PTSD), sleeping disorder (SD), obsessive-compulsive disorder (OCD) and suicide. A total of 43 meta-analyses involving 704 publications on 44 inflammation-related factors were included in the study. We calculated the effect size and statistical power for every inflammation-related factor in each disorder. Our analyses showed that well-powered case-control studies provided more consistent results than underpowered studies when one factor was meta-analysed by different researchers. After removing underpowered studies, 30 of the 44 inflammation-related factors showed significant alterations in at least one disorder based on well-powered meta-analyses. Eleven of them changed in patients of more than two disorders when compared with the controls. A few inflammation-related factors showed unique changes in specific disorders (e.g., IL-4 increased in BD, decreased in suicide, but had no change in MDD, ASD, PTSD and SCZ). MDD had the largest number of changes while SD has the least. Clustering analysis showed that closely related disorders share similar patterns of inflammatory changes, as genome-wide genetic studies have found. According to the effect size obtained from the meta-analyses, 13 inflammation-related factors would need <50 cases and 50 controls to achieve 80% power to show significant differences (p < 0.0016) between patients and controls. Changes in different states of MDD, SCZ or BD were also observed in various comparisons. Studies comparing first-episode SCZ to controls may have more reproducible findings than those comparing pre- and post-treatment results. Longitudinal, system-wide studies of inflammation regulation that can differentiate trait- and state-specific changes will be needed to establish valuable biomarkers.
摘要:
Except for an essential step for the pathology of multiple diseases including atherosclerosis and rheumatoid arthritis, inflammation is an imperative therapeutic target for developing novel approaches for pharmacological interventions. Thus, molecular understanding of inflammation not only revealed the mechanisms of drug action and their biological targets but also has spawned innovative maneuvers to influence multifaceted biological systems, providing new prospects for drug designing and suggesting important new implications for existing clinical medicine. Meanwhile, modulation of inflammation with the use of medicinal plants proposed an alternate to conventional therapeutic strategies for numerous ailments, particularly when suppression of inflammation is expected. In modern literature, several species of medicinal plants have been shown substantial antiinflammatory and immunomodulatory actions including inhibitory effects on suppression of cellular and humoral immunity, lymphocyte activation, and propagation of apoptosis. Herein, we reviewed the molecular pharmacology of inflammation, chemical components and biological activities of medicinal plants such as, curcumin from Curcuma longa, and epigallocatechin-3-gallate from Camellia sinensis as well as their mechanism of action during inflammation at molecular level. An extensive review of the literature and electronic databases was conducted, encompassing PubMed, GoogleScholar, ScienceDirect, medlineplus, www.clinicaltrial.gov, www.fda.gov, www.ema.europa.eu, www.drugbank.ca, TrialBulletin.com, www.theplantlist.org, and www.pharmacodia.com for assembling the information. Additionally, data was attained from books, ethnopharmacological literature, and relevant publications for essential elements of molecular mechanisms, signal transduction networks, transcription factors, complement system, reactive species, and clinical trials are selected for substantial understanding of biochemistry, pathophysiology as well as clinical importance of medicinal plants during inflammatory diseases.
摘要:
Parkinson's disease (PD) is a typical neurodegenerative disease and the pathological feature of which is the death of dopamine neurons in the substantia nigra region. At present, neuronal death caused by inflammatory cytokine-mediated neuroinflammation is being extensively studied. The nucleotide-binding oligomerization domain-, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome is an inflammatory complex existing in microglia. Its activation promotes the secretion of the inflammatory cytokine interleukin-1beta/18 (IL-1beta/18) and induces pyroptosis, a type of cell death that possesses the potential for inflammation, to rupture microglia to further release IL-1beta. In this review we focus on the mechanisms of activation of the NLRP3 inflammasome and pyroptosis and their inflammatory effects on the development of PD. In addition, we focus on some inhibitors of NLRP3 inflammatory pathways to alleviate the progression of PD by inhibiting central inflammation and provide new therapeutic strategies for the treatment of PD.
摘要:
The disorder of lipid metabolism is pathologically linked to hyperlipidemia, lipid storage disease, obesity and other related diseases. Intriguingly, recent studies have revealed that lipid metabolism disorders play an important role in carcinogenesis and development as well, since they cause abnormal expression of various genes, proteins, and dysregulation of cytokines and signaling pathways. More importantly, lipid-lowering drugs and anti-lipid per-oxidation treatment have been showing their advantages in clinic, in comparison with other anti-cancer drugs with high toxicity. Thus, further elucidation of molecular mechanism between lipid metabolism and cancer is essential in developing novel diagnostic biomarkers and therapeutic targets of human cancers.