期刊：
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH,2020年40(11):524-529 ISSN：1079-9907
通讯作者：
Liu, Yong
作者机构：
[Zhou, Hongfei; Weng, Wujin; Yu, Qi] Hunan Univ Chinese Med, Sch Med, Changsha, Peoples R China.;[Tang, Yamei] Cent South Univ, Dept Lab Med, Xiangya Hosp 2, Changsha, Peoples R China.;[Ding, Shan; Liu, Yong; Huang, Kai] Cent South Univ, Natl Clin Res Ctr Mental Disorders, Xiangya Hosp 2, Changsha, Peoples R China.;[Ding, Shan; Liu, Yong; Huang, Kai] Cent South Univ, Dept Psychiat, Xiangya Hosp 2, Changsha, Peoples R China.;[Ding, Shan; Liu, Yong; Huang, Kai] Hunan Key Lab Psychiat & Mental Hlth, Changsha, Peoples R China.
通讯机构：
[Liu, Yong] C;Cent South Univ, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Xiangya Hosp 2, 139 Rennin Middle Rd, Changsha 410011, Peoples R China.
关键词：
FES;platelet parameters;NLR;PLR;MLR
摘要：
Serotonin (5-HT) and inflammation are 2 major hypotheses in schizophrenia (SZ) pathogenesis, both of which involve platelets. However, the association between platelet and SZ has not been well studied. The aim of this study was to evaluate changes of platelet count (PLT), mean platelet volume (MPV), platelet-large cell ratio (P-LCR), platelet distribution width (PDW), and plateletcrit (PCT) in patients with first-episode schizophrenia (FES). Meanwhile, 3 inflammation markers, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR), were evaluated. Complete blood count of 106 FES patients, 82 first-episode depression (FED) patients, and 120 healthy controls (HCs) were compared. In addition, PLR, NLR, and MLR were calculated and compared among 3 groups. Our data suggested that PLT, MPV, P-LCR, PDW, PCT, NLR, PLR, and MLR in FES patients were significantly increased than those in the HCs (P < 0.01 or P < 0.05, respectively). PLT, PCT, PLR, and MLR in FED patients were significantly higher than those in the HCs (P < 0.01). However, no significant difference in MPV, P-LCR, and NLR was identified between FED patients and HCs (P > 0.05). Moreover, MPV, P-LCR, PDW, NLR, and MLR in FES patients were significantly higher than those in FED patients (P < 0.01 or P < 0.05, respectively). The elevation of PLT, MPV, P-LCR, PDW, PCT, NLR, PLR, and MLR in FES patients supported 5-HT and inflammation hypotheses in SZ pathogenesis. Further, our data suggested that increasing levels of MPV, P-LCR, PDW, NLR, and MLR might help to distinguish FES from FED. Clinical Trials.gov ID: 2018JJ2580
作者机构：
[Zhou, Bingping; Zhang, Wei; Li, Yaojin] Cent China Normal Univ, Sch Psychol, 152 Luoyu St, Wuhan 430079, Hubei, Peoples R China.;[Zhou, Bingping; Zhang, Wei; Li, Yaojin] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav CCNU, Wuhan, Peoples R China.;[Zhou, Bingping; Zhang, Wei; Li, Yaojin] Cent China Normal Univ, Hubei Human Dev & Mental Hlth Key Lab, Wuhan, Hubei, Peoples R China.;[Xue, Jinfeng] Hunan Univ Chinese Med, Med Sch, Changsha, Hunan, Peoples R China.;[Zhang-James, Yanli] SUNY Upstate Med Univ, Syracuse, NY 13210 USA.
通讯机构：
[Zhang, Wei] C;Cent China Normal Univ, Sch Psychol, 152 Luoyu St, Wuhan 430079, Hubei, Peoples R China.
摘要：
This study tested the causal link between Attention Deficit/Hyperactivity Disorder (ADHD) and Internet addiction (IA) and investigated motivational and executive dysfunction as explanatory mechanisms in this association. A sample of 682 young adults completed self-report measures both at Time1 and Time2, six-months apart, including 54 ADHD participants diagnosed by the Conners’ Adult ADHD Rating Scale and the Continuous Performance Test. According to the performance in four cognitive tasks, ADHD participants were classified into three groups based on the dual pathway model of ADHD: executive dysfunction (ED), motivational dysfunction (MD) and combined dysfunction (CD). Participants’ severity of IA symptoms was assessed using the self-report Chen IA Scale. Results indicated that ADHD scores at Time1 predicted IA scores at Time2 but not vice versa. ADHD participants were easier to be IA than controls, while the severity of IA among the three ADHD groups changed differently. The MD and CD groups became more excessively engaged in Internet use over the course of the six-months while the ED group was unchanged. These findings identify ADHD as a potential risk factor for IA and suggest that motivational dysfunction, characterized by an excessive preference for immediate reward over delayed rewards, is a better predictor of IA than executive dysfunction.
摘要：
Introduction It is well-known that altered hypothalamus-pituitary-adrenal (HPA) axis process has an important role in the neurodegenerative process in schizophrenia (SZ). However, this neurodegenerative mechanism has not been clarified in SZ. Therefore, the main purpose of this study was to determine HPA axis damage in the first-episode, unmedicated schizophrenia (FES) patients and chronic schizophrenia (CSZ) patients in comparison with healthy controls (HC) by means of quantitative analysis of the peripheral blood mRNA expression of glucocorticoid receptor (GR), GR transcripts containing exons 1B (GR-1B), and neuron specific enolase (NSE) genes and serum cortisol and NSE, a specific serum marker for neuronal damage. Methods In the present study, 43 FES patients, 39 CSZ, and 47 HC were included. The peripheral blood mRNA expressions for GR, GR-1B, and NSE genes were determined by real-time quantitative polymerase chain reaction (RT-qPCR). Serum cortisol and NSE were analyzed by electrochemiluminescence immunoassay technique. Results Levels of GR mRNA were significantly lower in FES and CSZ than that in HC. The expression of GR-1B mRNA was significantly decreased in CSZ when compared with that in FES. Levels of NSE mRNA were significantly lower in CSZ than that in FES patients or HC patients. CSZ patients showed significantly lower cortisol concentrations than FES and HC patients. FES patients showed significantly higher NSE concentrations than CSZ and HC. Conclusion Our findings support that there is disrupted HPA axis system in the SZ and suggest that CSZ patients suffer a greater HPA axis damage than FES patients. Our research implicated underlying GR mRNA dysregulation in SZ and the potential importance of the functional GR-1B transcription in CSZ.
摘要：
Objectives Cytokine activation and low complement levels are common in depression patients. This study is aimed at investigating the clinical significance of changes in serum concentrations of melatonin (MT), interleukin-6 (IL-6), homocysteine (hcy), and complement C3 and C4 in depression patients and relationships of them with depression activity. Methods A total of 95 depression patients, including first-episode group (n= 43) and recurrent group (n= 52), and 45 age- and gender-matched healthy controls (HC) were recruited. Serum levels of MT, IL-6, hcy, C3, and C4 in all samples were measured by using enzyme-linked immunosorbent assay (ELISA), chemiluminescence method, enzyme circulation method, and immuno-scatter turbidimetric assay, respectively. Results The serum MT, IL-6, and hcy levels in the first-episode group (113.08 +/- 5.06 pg/ml, 2.06 +/- 0.12 ng/L, and 13.87 +/- 0.45 mu mol/L), and recurrent group (117.63 +/- 4.63 pg/ml, 2.20 +/- 0.12 ng/L, and 13.61 +/- 0.46 mu mol/L) were significantly higher than those in the control group (89.50 +/- 5.10 pg/ml, 1.57 +/- 0.06 ng/L, and 11.34 +/- 0.40 mu mol/L). The serum levels of C3 in the first-episode group (0.95 +/- 0.02 ng/L) were significantly lower than those in the recurrent group (1.05 +/- 0.03 ng/L) and control group (1.12 +/- 0.03 ng/L). There was no significant difference in serum C4 level between each group. Conclusion These results suggest that higher serum MT, IL-6, and hcy levels were correlated with pathogenesis of depression.
摘要：
Schizophrenia (SZ) is a debilitating and heterogeneous disease. We hypothesized that the oxytocin (OXT) system, inflammation and one-carbon metabolism would have a link with SZ. In this study, serum OXT, OXT receptor (OXTR), interleukin-6 (IL-6), high sensitivity CRP (hsCRP) and homocysteine (Hcy) levels were measured in 52 first-episode schizophrenia (FES) patients and 41 healthy controls (HC) from the Second Xiangya Hospital of Central South University. Meanwhile, the mRNA expressions of OXT and OXTR genes were determined by real-time quantitative PCR. Serum OXT and OXTR levels were significantly lower in FES patients (518.96 +/- 22.22 and 174.60 +/- 17.11 pg/ml) than the HC group (711.58 +/- 40.57 and 252.15 +/- 20.62 pg/ml). Serum IL-6 and hsCRP levels showed no difference between the two groups (1.82 +/- 0.30 vs. 1.69 +/- 0.36 pg/ml, 0.66 (0.22, 1.07) vs. 0.31 (0.13, 0.91) mg/L), but serum Hcy levels were significantly higher in FES patients (20.18 +/- 1.83 vs. 15.24 +/- 0.82 mumol/ml). The FES patients (0.27 +/- 0.02 and 0.20 +/- 0.02) have relatively higher mRNA expressions of OXT and OXTR genes than the HC group (0.16 +/- 0.01 and 0.14 +/- 0.01). In summary, our results suggested the possible function of the OXT system and Hcy in the pathogenesis of SZ.
通讯机构：
[Zhang, Xi] H;Hunan Univ Chinese Med, Dept Pathol, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
关键词：
Qianlongtong;BPH;apoptosis
摘要：
Qianlongtong is a compound made from traditional Chinese herbs and it has proven to be very effective to treat patients with benign prostate hypertrophy. However, its mechanism is still unknown. This study is designed to investigate the effect of Qianlongtong on proliferation and apoptosis of hyperplastic prostate cells. Flow cytometry (FCM) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) were used to assess proliferation and apoptosis of hyperplastic prostate cells in the following groups: control group, tamoxifen group, and groups with low, moderate, and high dosage of Qianlongtong. Reverse transcription-polymerase chain reaction analysis was used to investigate the underlying mechanisms for increased apoptosis. Cells treated with Qianlongtong were mainly blocked in the G0/G1 phase. The apoptotic index of each group was significantly higher than that in the control group. The apoptotic index in the high- and moderate-dosage groups was similar to that in the tamoxifen group. The high- and moderate-dosage groups had lower Bcl-2 and higher Bax messenger RNA (mRNA) levels compared with the control group. Qianlongtong inhibits proliferation and promotes the apoptosis of hyperplastic prostate cells.
