Antidepressant-Like Effects and Cognitive Enhancement of Coadministration of Chaihu Shugan San and Fluoxetine: Dependent on the BDNF-ERK-CREB Signaling Pathway in the Hippocampus and Frontal Cortex
作者：
Yan, Lijing;Xu, Xia;He, Zhenyu;Wang, Sheng;Zhao, Linlin;...
期刊：
BioMed Research International ,2020年2020 ISSN：2314-6133
通讯作者：
Qiu, Xinjian;Huang, Huiyong
作者机构：
[Qiu, Xinjian; Xu, Xia; Yan, Lijing; Wang, Dongsheng] Cent South Univ, Xiangya Hosp, Inst Integrated Tradit Chinese & Western Med, Lab Ethnopharmacol, Changsha 410008, Hunan, Peoples R China.;[He, Zhenyu] Taizhou Hosp Integrated Tradit Chinese & Western, Taizhou 317500, Zhejiang, Peoples R China.;[Wang, Sheng] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou 310053, Zhejiang, Peoples R China.;[Zhao, Linlin] Cent South Univ, Dept Hlth Management, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China.;[Qiu, Juan] Cent South Univ, Dept Nucl Med, Xiangya Hosp 4, Changsha 410008, Hunan, Peoples R China.
通讯机构：
[Qiu, Xinjian] C;[Huang, Huiyong] H;Cent South Univ, Xiangya Hosp, Inst Integrated Tradit Chinese & Western Med, Lab Ethnopharmacol, Changsha 410008, Hunan, Peoples R China.;Hunan Univ Tradit Chinese Med, Inst Tradit Chinese Med Diag, Changsha 410208, Hunan, Peoples R China.
摘要：
Background. Fluoxetine (FLU) is the first-line and widely used medication for depression; however, FLU treatment is almost ineffective in 30%-40% of patients with depression. In addition, there are some problems in FLU treatment, such as delayed efficacy, large side effects, and poor tolerance. Chaihu Shugan San (CSS) is a classic and effective antidepressant Chinese herbal medicine that has been used in China for thousands of years. CSS or coadministration of CSS and FLU has become one of the most recommended methods in the treatment of depression in China. However, the specific pathways of CSS and coadministration of CSS and FLU for antidepressant are still unclear. Objective. This study was designed to evaluate the antidepressant effects of CSS and coadministration of CSS and FLU. Methods. The chronic unpredictable mild stress (CUMS) rat model was used to simulate depression. 120 healthy adult male Sprague-Dawley (SD) rats were randomly divided into seven groups: the control group, CUMS group, low-dose CSS group, high-dose CSS group, FLU group, coadministration of low-dose CSS and FLU group, and coadministration of high-dose CSS and FLU group. The rats in different groups were given different interventions. Then, the depression-like behavior and cognitive function were evaluated by the sucrose preference test (SPT), forced swimming test (FST), open field test (OFT), and Y-maze test. What is more, the antidepressant mechanism of CSS and coadministration of CSS and FLU were studied through BDNF mRNA, ERK mRNA, CREB mRNA, BDNF, p-ERK/ERK, and p-CREB/CREB levels in the hippocampus and frontal cortex by Western blot and RT-PCR. Results. Compared with the CUMS group, CSS and coadministration of CSS and FLU could alleviate the depressive symptoms and improve cognitive function in CUMS rats (p<0.05); CSS and coadministration of CSS and FLU could increase the expression of BDNF, p-CREB/CREB, p-ERK/ERK, and BDNF mRNA, CREB mRNA, and ERK mRNA in the hippocampus and frontal cortex (p<0.05). Besides, the high-dose CSS combined with the fluoxetine group was significantly better than the fluoxetine group and CSS group (p<0.05). Discussion and Conclusion. Finally, we found that both CSS and coadministration of CSS and FLU play an antidepressant role, which may be due to the regulation of the BDNF/ERK/CREB signaling pathway in the hippocampus and frontal cortex. Among them, the coadministration of CSS and FLU can enhance the antidepressant effect of CSS or FLU alone, and the underlying mechanism needs further investigation. © 2020 Lijing Yan et al.
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Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients
作者：
Liu, Yong;Tao, Huai;Yang, Xiudeng;Huang, Kai;Zhang, Xianghui;...
期刊：
Frontiers in Psychiatry ,2019年10(APR):217 ISSN：1664-0640
通讯作者：
Li, Cunyan
作者机构：
[Zhang, Xianghui; Liu, Yong; Huang, Kai] Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China.;[Zhang, Xianghui; Liu, Yong; Huang, Kai] China Natl Clin Res Ctr Mental Disorders Xiangya, Changsha, Hunan, Peoples R China.;[Zhang, Xianghui; Liu, Yong; Huang, Kai] China Natl Technol Inst Mental Disorders, Changsha, Hunan, Peoples R China.;[Zhang, Xianghui; Liu, Yong; Huang, Kai] Cent S Univ, Mental Hlth Inst, Changsha, Hunan, Peoples R China.;[Zhang, Xianghui; Liu, Yong; Huang, Kai] Hunan Key Lab Psychiat & Mental Hlth, Changsha, Hunan, Peoples R China.
通讯机构：
[Li, Cunyan] H;Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Dept Lab Med, Changsha, Hunan, Peoples R China.
关键词：
FES;Hcy;IL-6;OXT;OXTR;hsCRP
摘要：
Schizophrenia (SZ) is a debilitating and heterogeneous disease. We hypothesized that the oxytocin (OXT) system, inflammation and one-carbon metabolism would have a link with SZ. In this study, serum OXT, OXT receptor (OXTR), interleukin-6 (IL-6), high sensitivity CRP (hsCRP) and homocysteine (Hcy) levels were measured in 52 first-episode schizophrenia (FES) patients and 41 healthy controls (HC) from the Second Xiangya Hospital of Central South University. Meanwhile, the mRNA expressions of OXT and OXTR genes were determined by real-time quantitative PCR. Serum OXT and OXTR levels were significantly lower in FES patients (518.96 +/- 22.22 and 174.60 +/- 17.11 pg/ml) than the HC group (711.58 +/- 40.57 and 252.15 +/- 20.62 pg/ml). Serum IL-6 and hsCRP levels showed no difference between the two groups (1.82 +/- 0.30 vs. 1.69 +/- 0.36 pg/ml, 0.66 (0.22, 1.07) vs. 0.31 (0.13, 0.91) mg/L), but serum Hcy levels were significantly higher in FES patients (20.18 +/- 1.83 vs. 15.24 +/- 0.82 mumol/ml). The FES patients (0.27 +/- 0.02 and 0.20 +/- 0.02) have relatively higher mRNA expressions of OXT and OXTR genes than the HC group (0.16 +/- 0.01 and 0.14 +/- 0.01). In summary, our results suggested the possible function of the OXT system and Hcy in the pathogenesis of SZ.
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Effect of Clozapine on Anti-N-Methyl-D-Aspartate Receptor Encephalitis With Psychiatric Symptoms: A Series of Three Cases.
作者：
Yang, Ping;Li, Liang;Xia, Shuaishuai;Zhou, Bin;Zhu, Yong;...
期刊：
Frontiers in Neuroscience ,2019年13(APR):315 ISSN：1662-4548
通讯作者：
Huang, Huiyong;Li, Feng
作者机构：
[Yang, Ping; Zhou, Bin; Zhou, Gaoya; Tu, Erwen; Zhu, Yong] Hunan Univ Chinese Med, Dept Psychiat, Hunan Brain Hosp, Clin Med Sch, Changsha, Hunan, Peoples R China.;[Li, Liang; Huang, Huiyong; Li, F; Li, Feng; Xia, Shuaishuai] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Changsha, Hunan, Peoples R China.;[Huang, Tianho] Shanghai Inst Measurement & Testing Technol, Shanghai, Peoples R China.;[Li, Feng] Univ Calif Los Angeles, Sch Dent, Los Angeles, CA 90024 USA.
通讯机构：
[Huang, HY; Li, F] H;[Li, Feng] U;Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Changsha, Hunan, Peoples R China.;Univ Calif Los Angeles, Sch Dent, Los Angeles, CA 90024 USA.
关键词：
anti-NMDA receptor encephalitis;antipsychotic therapy;clozapine;hormone;intravenous immunoglobulin;psychiatric symptoms
摘要：
The main clinical manifestations of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis are acute or subacute seizures, cognition impairment, and psychiatric symptoms. Nowadays, the scheme of antipsychotic therapy for this disease has not been established. This study reports three cases of anti-NMDAR encephalitis with psychiatric symptoms. The anti-NMDAR antibodies in cerebrospinal fluid (CSF) and serum were positive. The psychiatric symptoms still existed after intravenous immunoglobulin (IVIG) treatment; thus, clozapine was used for antipsychotic therapy. Case 1 was a 37-year-old man who suffered from bad mood and suicide behaviors for 1 month. Hallucination and delusion still existed after IVIG treatment and hormone therapy, and the symptoms were relieved when given clozapine for 12 months. Case 2 was a 28-year-old man who was admitted to our hospital due to injuring other people and destructive behaviors for 2 days. He showed irritability, bad temper, declined cognition, and severe delusion of persecution after IVIG treatment and hormone therapy, but the psychiatric symptoms disappeared when given clozapine for 3 months. Case 3 was a 23-year-old man who suffered from headache and babbing for 7 days. Symptoms such as irritability, bad temper, babbing, and injuring other people still existed after IVIG treatment and hormone therapy, but they disappeared when given clozapine for 2 months. Therefore, we suggest that during the treatment of anti-NMDAR encephalitis with psychiatric symptoms, if the anti-NMDAR antibodies in CSF and serum were positive, and psychiatric symptoms could not be controlled after IVIG and hormone therapy, clozapine may work.
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Increased Serum C3 and Decreased UA in Patients of Bipolar Disorder in Chinese Han Population
作者：
Yang, Xiudeng;Tao, Huai;Xiao, Ledong;Li, Cunyan;Tang, Yamei;...
期刊：
Frontiers in Psychiatry ,2018年9(AUG):381 ISSN：1664-0640
通讯作者：
Liu, Yong
作者机构：
[Xiao, Ledong; Yang, Xiudeng] Shaoyang Univ, Affiliated Hosp 1, Dept Lab Med, Shaoyang, Peoples R China.;[Tao, Huai] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha, Hunan, Peoples R China.;[Li, Cunyan] Hunan Normal Univ, Affiliated Hosp, Hunan Prov Peoples Hosp, Dept Lab Med, Changsha, Hunan, Peoples R China.;[Tang, Yamei] Cent S Univ, Xiangya Hosp 2, Dept Lab Med, Changsha, Hunan, Peoples R China.;[Liu, Yong] Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China.
通讯机构：
[Liu, Yong] C;[Liu, Yong] H;Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China.;Cent S Univ, Mental Hlth Inst, Changsha, Hunan, Peoples R China.;Hunan Key Lab Psychiat & Mental Hlth, Changsha, Hunan, Peoples R China.
关键词：
C3;C4;bipolar disorder;hypersensitive C-reactive protein;uric acid
摘要：
The aim of this study is to explore the changes and clinical significance of serum C3, C4, hypersensitive C-reactive protein (hsCRP) and uric acid (UA) in patients of bipolar disorder (BD). In this case-control study, we recruited 141 BD patients from The Second Xiangya Hospital, Central South University, and 151 age and gender matched healthy controls (HC) from the health management central of The Second Xiangya Hospital. These patients were divided into two subgroups based on medicines use: 91 patients were treated with psychiatric drugs and 50 patients were drugs free, or four subgroups based on mood states: 54 patients in manic/hypomanic phase, 30 patients in depressive phase, 52 patients in euthymic phase and 5 patients in mixed phase. Serum levels of C3, C4, hsCRP and UA were measured in all subjects. The serum C3 levels in BD patients (0.9981 ± 0.1849 g/L) were significantly lower than that in HC group (1.0637 ± 0.2186 g/L), especially the drugs free subgroup and the euthymic subgroup (0.975 ± 0.153 and 0.983 ± 0.182 g/L), while the serum UA levels were significantly higher (354.6 ± 90.4 vs. 332.9 ± 88.7 μmol/L), especially the drug-treated subgroup and manic/hypomanic subgroup (361.56 ± 93.20 and 376.70 ± 88.89 μmol/L), and rates of hyperuricaemia (31.91 vs. 17.88%) were significantly higher in BD patients than in HC group. The serum C4 and hsCRP levels in HC group showed no significant difference with BD patients in whole or those subgroups. These findings suggested that the complement and purinergic systems of BD patients might be disrupted, the UA levels could be a potential marker in manic phase and the C3 might be the marker of therapeutic evaluation of BD patients. © 2018 Yang, Tao, Xiao, Li, Tang and Liu.
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Assessment of a combination of Serum Proteins as potential biomarkers to clinically predict Schizophrenia
作者：
Li, Cunyan;Tao, Huai
（ ;Yang, Xiudeng;Zhang, Xianghui;Liu, Yong;...
期刊：
International Journal of Medical Sciences ,2018年15(9):900-906 ISSN：1449-1907
通讯作者：
Tang, Yamei
作者机构：
[Li, Cunyan] Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Lab Med, Affiliated Hosp 1, Changsha 410005, Hunan, Peoples R China.;[Tao, Huai] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha 410208, Hunan, Peoples R China.;[Yang, Xiudeng; Tang, Aiguo; Tang, Yamei] Cent S Univ, Xiangya Hosp 2, Dept Lab Med, Changsha 410011, Hunan, Peoples R China.;[Zhang, Xianghui; Liu, Yong] Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China.;[Zhang, Xianghui; Liu, Yong] Cent S Univ, Mental Hlth Inst, Changsha, Hunan, Peoples R China.
通讯机构：
[Tang, Yamei] C;Cent S Univ, Xiangya Hosp 2, Dept Lab Med, Changsha 410011, Hunan, Peoples R China.
关键词：
BDNF;DNMT1;ErbB4;NRG1;Schizophrenia;TET1;biomarker
摘要：
Schizophrenia (SZ) is a devastating psychiatric disorder. Validation of potential serum biomarkers during first-episode psychosis (FEP) is especially helpful to understand the onset and prognosis of this disorder. To address this question, we examined multiple blood biomarkers and assessed the efficacy to diagnose SZ. The expression levels of Neuregulin1 (NRG1), ErbB4, brain-derived neurotrophic factor (BDNF), DNA methyltransferases 1 (DNMT1) and ten-eleven translocation 1 (TET1) proteins in peripheral blood of 53 FEP patients and 57 healthy controls were determined by enzyme-linked immunosorbent assay (ELISA). Multivariable logistic regression including biomarker concentration as covariates was used to predict SZ. Differentiating performance of these five serum protein levels was analyzed by Receiver Operating Characteristic (ROC) curve analysis. We found that patients with SZ present a higher concentration of DNMT1, and TET1 in peripheral blood, but a lower concentration of NRG1, ErbB4 and BDNF than controls. Multivariable logistic regression showed that ErbB4, BDNF and TET1 were independent predictors of SZ, and when combined, provided high diagnostic accuracy for SZ. Together, our findings highlight that altered expression of NRG1, ErbB4, BDNF, DNMT1 and TET1 are involved in schizophrenia development and they may serve as potential biomarkers for the diagnosis of the schizophrenia. Therefore, our study provides evidence that combination of ErbB4, BDNF and TET1 biomarkers could greatly improve the diagnostic performance. © Ivyspring International Publisher.
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Effect of postoperative systemic antipsychotic therapy on psychiatric recurrence in patients with meningiomas
作者：
Yang, Ping;Li, Liang
（ ;Li, Mao-Sheng;Zhou, Bin;Kuang, Wei-Ping;...
期刊：
Oncology Letters ,2018年16(1):956-962 ISSN：1792-1074
通讯作者：
Huang, Hui-Yong
（ 作者机构：
[Yang, Ping; Zhou, Bin; Li, Mao-Sheng; Kuang, Wei-Ping] Hunan Brain Hosp, Dept Psychiat, Changsha 410007, Hunan, Peoples R China.;[Li, Liang; Huang, Hui-Yong] Hunan Univ Chinese Med, Prov Key Lab Tradit Chinese Med Diagnost, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.;[Li, Liang] Hunan Univ Chinese Med, Dept Anat, Changsha 410208, Hunan, Peoples R China.
通讯机构：
[Huang, Hui-Yong] H;Hunan Univ Chinese Med, Prov Key Lab Tradit Chinese Med Diagnost, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
关键词：
antipsychotic treatment;meningiomas;psychiatric symptoms
摘要：
A number of patients with meningiomas and psychiatric disorders will suffer psychiatric symptom recurrence following tumorectomies. The present study reported a retrospective analysis regarding 42 cases of patients with meningiomas using complete clinical follow-up data from June 2005 to June 2013. The patients were divided into the systemic antipsychotic (SP) group (n=20) following 6months of postoperative SP therapy and the none-SP (NSP) group (n=22), who did not receive postoperative antipsychotic treatment. Patients were assessed using the Positive and Negative Syndrome Scale (PANSS) and Brief Psychiatric Rating Scale (BPRS) at the time points of prior to surgery, immediately following surgery, and 6 months, 12 months and 3 years following surgery. The effective rate, recurrence rate, rehospitalization rate and survival analysis were calculated. The BPRS score and PANSS scores (including PANSS positive, PANSS negative, PANSS general psychopathology and PANSS overall) in the SP group at 6 months, 12 months and 3 years following surgery were significantly decreased compared with the NSP group (P<0.05). The effective rate was 95, 90 and 90% at 6 months, 12 months and 3 years, respectively, in the SP group, whilst it was 68.2, 63.6 and 59%, respectively, in the NSP group, which was statistically significant (χ2 =4.89, χ2 =4.01 and χ2 =5.12; P<0.05). The recurrence rate of the SP group was 0, 5 and 10% at 6 months, 12 months and 3 years, respectively, whilst in the NSP group it was 22.7, 31.8 and 54.5%, respectively, which was statistically significant (χ2 =5.16, χ2 =4.89 and χ2 =9.34; P<0.05). The rehospitalization rate of the SP group was 0, 0 and 5% at 6 months, 12 months and 3 years, respectively, whilst in the NSP group it was 13.6, 22.7 and 36.4%, respectively, and the data at 12 months and 3 years was statistically significant (χ2 =5.16 and χ2 =6.12; P<0.05). Kaplan-Meier survival analysis indicated that the accumulative survival rates of recurrence and rehospitalization in the SP group were improved compared with the NSP group. The log-rank of recurrence was χ2 =9.369 (P=0.002) and the log-rank of rehospitalization was χ2 =6.330 (P=0.012). In conclusion, postoperative SP therapy is of great importance to the consolidation of mental symptoms in patients with meningiomas and psychiatric symptoms, and it may significantly reduce the recurrence and rehospitalization rates. © 2018, Spandidos Publications. All rights reserved.
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Effect of Peony-Glycyrrhiza Decoction on Amisulpride induced Hyperprolactinemia in Women with Schizophrenia: A Preliminary Study
作者：
Yang, Ping;Li, Liang
（ ;Yang, Dong;Wang, Chaoying;Peng, Hongli;...
期刊：
Evidence-Based Complementary and Alternative Medicine ,2017年2017:7901670 ISSN：1741-427X
通讯作者：
Liu, Xuejun;Huang, Huiyong
（ 作者机构：
[Yang, Ping; Peng, Hongli; Liu, Xuejun; Yang, Dong; Wang, Chaoying] Brains Hosp Hunan Prov, Dept Psychiat, Changsha, Hunan, Peoples R China.;[Li, Liang; Huang, Huiyong] Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Changsha, Hunan, Peoples R China.
通讯机构：
[Huang, Huiyong] H;[Liu, Xuejun] B;Brains Hosp Hunan Prov, Dept Psychiat, Changsha, Hunan, Peoples R China.;Hunan Univ Chinese Med, Prov Key Lab TCM Diagnost, Changsha, Hunan, Peoples R China.
摘要：
Objective. The aim of this study is to observe the effect of Peony-Glycyrrhiza Decoction (PGD) on hyperprolactinemia in women with schizophrenia induced by Amisulpride. Material and Methods. A total of 41 female schizophrenia patients receiving Amisulpride were randomly divided into placebo (n=20) and PGD groups (n=21). Maintaining the original Amisulpride dose, the two groups were given placebo and PGD, respectively. The levels of Prolactin (PRL) and other hormones were measured on the initial day and at weeks 4 and 8 after treatment. Changes of clinical symptoms in patients with hyperprolactinemia were observed. The PANSS scores were recorded to assess the psychotic symptoms. Results. Compared with placebo group, level of PRL decreased while Progesterone increased remarkably in the PGD group at weeks 4 and 8 (p<0.01), and level of Estradiol in the PGD group increased significantly at week 8 (p<0.05). There were no differences in PANSS scores and biochemical indexes between two groups at weeks 4 and 8. Conclusion. PGD can improve symptoms of hyperprolactinemia and hormone levels in women with schizophrenia caused by Amisulpride, without affecting their mental symptoms and biochemical indexes. © 2017 Ping Yang et al.
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