Automatic detection and recognition of multiple macular lesions in retinal optical coherence tomography images with multi-instance multilabel learning
作者：
Fang, Leyuan;Yang, Liumao;Li, Shutao* ;Rabbani, Hossein;Liu, Zhimin;...
期刊：
Journal of Biomedical Optics ,2017年22(6):066014 ISSN：1083-3668
通讯作者：
Li, Shutao
作者机构：
[Yang, Liumao; Fang, Leyuan; Li, Shutao] Hunan Univ, Coll Elect & Informat Engn, Changsha, Hunan, Peoples R China.;[Rabbani, Hossein] Isfahan Univ Med Sci, Med Image & Signal Proc Res Ctr, Esfahan, Iran.;[Liu, Zhimin; Peng, Qinghua; Chen, Xiangdong] Hunan Univ Chinese Med, Dept Ophthalmol, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.
通讯机构：
[Li, Shutao] H;Hunan Univ, Coll Elect & Informat Engn, Changsha, Hunan, Peoples R China.
关键词：
optical coherence tomography;image processing;automated detection;macular lesions;multiple labels;Optical coherence tomography;Sensors;Eye
摘要：
Detection and recognition of macular lesions in optical coherence tomography (OCT) are very important for retinal diseases diagnosis and treatment. As one kind of retinal disease (e.g., diabetic retinopathy) may contain multiple lesions (e.g., edema, exudates, and microaneurysms) and eye patients may suffer from multiple retinal diseases, multiple lesions often coexist within one retinal image. Therefore, one single-lesion-based detector may not support the diagnosis of clinical eye diseases. To address this issue, we propose a multi-instance multilabel-based lesions recognition (MIML-LR) method for the simultaneous detection and recognition of multiple lesions. The proposed MIML-LR method consists of the following steps: (1) segment the regions of interest (ROIs) for different lesions, (2) compute descriptive instances (features) for each lesion region, (3) construct multilabel detectors, and (4) recognize each ROI with the detectors. The proposed MIML-LR method was tested on 823 clinically labeled OCT images with normal macular and macular with three common lesions: epiretinal membrane, edema, and drusen. For each input OCT image, our MIML-LR method can automatically identify the number of lesions and assign the class labels, achieving the average accuracy of 88.72% for the cases with multiple lesions, which better assists macular disease diagnosis and treatment. ©2017 Society of Photo-Optical Instrumentation Engineers (SPIE).
语种：
英文
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Automatic classification of retinal three-dimensional optical coherence tomography images using principal component analysis network with composite kernels
作者：
Fang, Leyuan;Wang, Chong;Li, Shutao* ;Yan, Jun;Chen, Xiangdong;...
期刊：
Journal of Biomedical Optics ,2017年22(11):116011 ISSN：1083-3668
通讯作者：
Li, Shutao
作者机构：
[Wang, Chong; Yan, Jun; Fang, Leyuan; Li, Shutao] Hunan Univ, Coll Elect & Informat Engn, Changsha, Hunan, Peoples R China.;[Chen, Xiangdong] Hunan Univ Chinese Med, Dept Ophthalmol, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.;[Rabbani, Hossein] Isfahan Univ Med Sci, Med Image & Signal Proc Res Ctr, Esfahan, Iran.
通讯机构：
[Li, Shutao] H;Hunan Univ, Coll Elect & Informat Engn, Changsha, Hunan, Peoples R China.
关键词：
optical coherence tomography;principal component analysis network;composite kernel;retinal disease;image classification;Optical coherence tomography;Principal component analysis;Composites;3D image processing;Image classification;Feature extraction;3D modeling;Network security;Convolution;Coherence (optics)
摘要：
We present an automatic method, termed as the principal component analysis network with composite kernel (PCANet-CK), for the classification of three-dimensional (3-D) retinal optical coherence tomography (OCT) images. Specifically, the proposed PCANet-CK method first utilizes the PCANet to automatically learn features from each B-scan of the 3-D retinal OCT images. Then, multiple kernels are separately applied to a set of very important features of the B-scans and these kernels are fused together, which can jointly exploit the correlations among features of the 3-D OCT images. Finally, the fused (composite) kernel is incorporated into an extreme learning machine for the OCT image classification. We tested our proposed algorithm on two real 3-D spectral domain OCT (SD-OCT) datasets (of normal subjects and subjects with the macular edema and age-related macular degeneration), which demonstrated its effectiveness. © 2017 Society of Photo-Optical Instrumentation Engineers (SPIE).
语种：
英文
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Study of hemoglobin response to mid-ultraviolet (UVB) radiation using micro-Raman spectroscopy
作者：
Huang, Y. Y.;Li, N.;Zhou, S. N.;Huang, Z. T.;Zhuang, Z. F.*
期刊：
Applied Physics B: Lasers and Optics ,2017年123(9):1-7 ISSN：0946-2171
通讯作者：
Zhuang, Z. F.
作者机构：
[Zhuang, Z. F.; Huang, Y. Y.; Li, N.] South China Normal Univ, Coll Biophoton, MOE Key Lab Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China.;[Zhuang, Z. F.; Huang, Y. Y.; Li, N.] South China Normal Univ, Coll Biophoton, Lab Photon Chinese Med, Guangzhou 510631, Guangdong, Peoples R China.;[Huang, Y. Y.] South China Normal Univ, Lab Photon Informat Technol, Guangzhou 510631, Guangdong, Peoples R China.;[Zhou, S. N.] Hunan Univ Chinese Med, Hosp 1, Changsha 410007, Hunan, Peoples R China.;[Huang, Z. T.] Guzhen Prod Promot Ctr, Zhongshan, Peoples R China.
通讯机构：
[Zhuang, Z. F.] S;South China Normal Univ, Coll Biophoton, MOE Key Lab Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China.;South China Normal Univ, Coll Biophoton, Lab Photon Chinese Med, Guangzhou 510631, Guangdong, Peoples R China.
摘要：
Confocal micro-Raman spectroscopy is employed to monitor the damage to haemoglobin from mid-ultraviolet (UVB) radiation. We obtained the Raman spectra of an erythrocyte, which indicated that a peroxidation reaction occurs after UVB radiation. Further, the surface enhanced Raman scattering (SERS) spectra of isolated haemoglobin show that the intensities of the 1375 and 1399 cm<sup>−1</sup>bands, which are markers of haem aggregation, obviously increase with prolonged UVB irradiation. This increase reveals that haem aggregation occurs in the peroxidation of erythrocytes. The UV–Vis spectra of isolated haemoglobin indicate that the Soret band, which is indicative of excitonic interactions in the aggregated haems, has a redshift (~12 nm) after 30 min of UVB irradiation of erythrocytes. It can be deduced that an excitonic interaction occurs in the aggregated haems, which is caused by haemoglobin denaturation following UVB irradiation. In addition, the changes of the Raman marker bands during aggregation primarily originate from excitonic interactions. Throughout the process, a higher UVB radiation dose causes greater damage to haemoglobin. ©2017, Springer-Verlag GmbH Germany.
语种：
英文
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探测器交会小天体的UPF自主导航方案
作者：
董克芳;田心义;孙绍裘;朱付平;周昭辉;...
期刊：
吉林大学学报（工学版） ,2007年37(3):691-695 ISSN：1671-5497
通讯作者：
Li, P.(lipeng@astro.hit.edu.cn)
作者机构：
[董克芳; 田心义; 孙绍裘; 周昭辉; 孙达武] 湖南中医学院第二附属医院骨科;[朱付平; 肖符武] 湖南中医学院第一附属医院骨科
通讯机构：
Deep Space Exploration Research Center, Harbin Institute of Technology, China
关键词：
飞行器控制与导航技术;自主光学导航;Unscented粒子滤波;非线性非高斯;自主轨道确定
摘要：
采用基于目标天体信息的光学导航方案实现探测器交会小天体，利用导航相机提高了定轨精度和星历精度。在此基础上，针对深空导航的轨道确定过程中可能存在的初始估计信息误差较大、状态及量测误差不服从高斯分布等问题，将UPF（Unscented Particle Filter）引入到导航方案中。该方案利用UPF在处理非线性非高斯问题上的优势，克服了EKF、UKF、PF等传统滤波方案对非线性非高斯状态模型、量测模型的近似处理所带来的影响。数值仿真表明了该方案的可行性。
语种：
中文
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反相高效液相色谱法测定大鼠血浆中补阳还五汤中黄芪甲苷的含量及药动学研究
作者：
贺福元;刘平安;邓凯文;刘文龙;邓常青
期刊：
中国药学杂志 ,2005年40(21):1647-1649 ISSN：1001-2494
通讯作者：
He, F.-Y.
作者机构：
[刘平安; 贺福元; 刘文龙] Department of Pharmaceutics, Hunan College of TCM, Changsha 410007, China;[贺福元] School of Pharmacy, Chengdu University of TCM, Chengdu 610075, China;[邓常青] Institute of TCM's Diagnosis, Hunan College of TCM, Changsha 410007, China;[邓凯文] First Affiliated Hospital, Hunan College of TCM, Changsha 410007, China
通讯机构：
[He, F.-Y.] D;Department of Pharmaceutics, Hunan College of TCM, China
关键词：
补阳还五汤;总苷;黄芪甲苷;反相高效液相色谱法;药动学
摘要：
目的对大鼠血浆补阳还五汤中黄芪甲苷的含量进行了测定,并进行了药动学研究.方法采用反相高效液相色谱法测定,其条件为色谱柱:C18柱(4.6 mm×250 mm,5 μm);检测波长:203nm;流动相:乙腈-水(35:65),流速:1 mL·min-1;柱压:(15.17±0.4137)MPa;温度:45℃.药动学参数采用3P87软件处理.结果血浆样品中黄芪甲苷线性范围为2.4～12μg,r=0.999 6,回收率为100.2%,RSD为1.100%.黄芪甲苷药动学参数:复方:t1/2α为1.392 h;t1/2β为14.24h;K12为0.162 4 h-1;K21为0.304 5 h-1;K10为0.079 58 h-1;总苷:t1/2α为2.641 h;t1/2β为37.12 h;K12为0.1283 h-1;K21为0.1071 h-1;K10为0.045 74h-1.结论该法快速、简便,准确.补阳还五汤复方及总苷中黄芪甲苷药动学为二室模型.中药复方成分组合对药动学参数有一定影响.
语种：
中文
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