作者机构：
[郭志华] Department of Internal Medicine, Hospital of Hunan College of Traditional Chinese Medicine, Changsha 410005 Hunan Province, China;[袁肇凯; 王东生] Institute of Diagnosis, Hunan College of Traditional Chinese Medicine, Changsha 410005 Hunan Province, China
通讯机构：
[Guo, Z.-H.] D;Department of Internal Medicine, Hospital of Hunan College of Traditional Chinese Medicine, China
关键词：
胰岛素抗药性;脂类/血液;血压;血糖;中药疗法
摘要：
Aim: To explore the effects of sitai tablet on blood pressure, blood lipid, blood sugar and insulin of rats with insulin resistance syndrome(IRS). Methods: A total of 40 male clean SD rats were divided into normal control group, model group, sitai group and captopril group by randomized block design. The rats were fed with high-fat high sugar diet for 8 weeks to induce IRS. Then, sitai tablets were given to rats with IRS to observe the influence of sitai tablet on blood pressure, blood sugar, blood lipid, insulin levels and insulin sensitivity index(ISI) of them. Results: The systolic pressure reduced from(158±8), (157±7) mm Hg before treatment to(128±4), (110±2)mm Hg after treatment in sitai group and captoril group respectively. There was also significant difference on systolic pressure of between sitai group, captopril group and model group [(165±6)mm Hg] (t=11.86-28.99, P < 0.01). In sitai group, the total cholesterol(TC), triacylycerol(TG) decreased clearly than those in model group(t=44.27, 9.14, P < 0.01), but high density lipoprotein cholesterol (HDL-C) increased(t=703, P < 0.01). There were increased fasting insulin (FINS) and decreased ISI in model group. There was significant difference on these indes between model group and normal control group(t =7.14, 9.35, P < 0.01). The insulin resistance was evident so that the model was successfully established. The fasting blood sugar and FINS all reduced when comparing it between sitai group, captopsil group with model group, there was significant difference(t=11.95, 6.71, P < 0.01). When comparing the fasting blood sugar in captoril group and sitai group, there was also difference(t=8.33, P < 0.01). The ISI all increased in sitai group (t=9.82, 9.35, P < 0.01). Conclusion: Sitai tablet can remarkably reduce the blood pressure, blood sugar and blood fat, and increase the sensibility of insulin so that it can improve the general effects of IRS.
