Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer
作者:
Wang, Zhiqi;Li, Sai;Cao, Yu;Tian, Xuefei;Zeng, Rong;...
期刊:
Oxidative Medicine and Cellular Longevity,2016年2016:9875298 ISSN:1942-0900
通讯作者:
Cao, Deliang
作者机构:
[Tian, Xuefei; Wang, Zhiqi; Li, Sai; Liao, Duan-Fang; Cao, Deliang; Zeng, Rong] Hunan Univ Chinese Med, Dept Pharmacol, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha 410208, Hunan, Peoples R China.;[Tian, Xuefei; Wang, Zhiqi; Li, Sai; Liao, Duan-Fang; Cao, Deliang; Zeng, Rong] Hunan Univ Chinese Med, Key Lab Coll, Changsha 410208, Hunan, Peoples R China.;[Tian, Xuefei; Wang, Zhiqi; Li, Sai; Liao, Duan-Fang; Cao, Deliang; Zeng, Rong] Hunan Univ Chinese Med, Univ Hunan Prov Cytobiol & Mol Biotechnol, Changsha 410208, Hunan, Peoples R China.;[Cao, Yu; Cao, Deliang] So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, 913 N Rutledge St, Springfield, IL 62794 USA.
通讯机构:
[Cao, Deliang] H;[Cao, Deliang] S;Hunan Univ Chinese Med, Dept Pharmacol, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha 410208, Hunan, Peoples R China.;Hunan Univ Chinese Med, Key Lab Coll, Changsha 410208, Hunan, Peoples R China.;Hunan Univ Chinese Med, Univ Hunan Prov Cytobiol & Mol Biotechnol, Changsha 410208, Hunan, Peoples R China.
摘要:
Oxidative stress has long been known as a pathogenic factor of ulcerative colitis (UC) and colitis-associated colorectal cancer (CAC), but the effects of secondary carbonyl lesions receive less emphasis. In inflammatory conditions, reactive oxygen species (ROS), such as superoxide anion free radical (O 2 -), hydrogen peroxide (H<inf>2</inf>O<inf>2</inf>), and hydroxyl radical (H O ), are produced at high levels and accumulated to cause oxidative stress (OS). In oxidative status, accumulated ROS can cause protein dysfunction and DNA damage, leading to gene mutations and cell death. Accumulated ROS could also act as chemical messengers to activate signaling pathways, such as NF-B and p38 MAPK, to affect cell proliferation, differentiation, and apoptosis. More importantly, electrophilic carbonyl compounds produced by lipid peroxidation may function as secondary pathogenic factors, causing further protein and membrane lesions. This may in turn exaggerate oxidative stress, forming a vicious cycle. Electrophilic carbonyls could also cause DNA mutations and breaks, driving malignant progression of UC. The secondary lesions caused by carbonyl compounds may be exceptionally important in the case of host carbonyl defensive system deficit, such as aldo-keto reductase 1B10 deficiency. This review article updates the current understanding of oxidative stress and carbonyl lesions in the development and progression of UC and CAC. ©2016 Zhiqi Wang et al.
语种:
英文
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考虑剪胀性和应变软化的粉细砂双屈服面本构模型
作者:
杨琼梁;袁佳敏;黄星雨;颜冲;杨仁义;...
期刊:
水利学报,2008年39(2):129-136 ISSN:0559-9350
通讯作者:
Huang, M.-S.(mshuang@mail.tongji.edu.cn)
作者机构:
[杨琼梁; 袁佳敏; 黄星雨; 李博杨; 颜红] 湖南中医药大学药学院;[颜冲] 湖南中医药大学医学院;[杨仁义] 湖南中医药大学中西医结合学院;[苏啟后] 湖南中医药大学中医学院
通讯机构:
Tongji University, China
关键词:
粉细砂;剪胀性;应变软化;双屈服面
摘要:
针对上海粉细砂不存在唯一临界状态线的特点,对传统的砂土本构模型进行了改进,提出了一个能合理描述粉细砂剪胀性和应变软化特性的弹塑性本构模型。该模型采用双屈服面形式,可同时反映剪切变形及压缩变形机理。模型对传统修正剑桥模型中的剪胀性公式进行了改进,考虑了反映塑性体积应变由正转为负时对应的特征状态应力比与初始有效围压的相关性。为了描述应变软化特性,提出了一个利用残余状态应力比和峰值应力比的应变软化公式,可较为合理地反映粉细砂的应变软化特性。通过对上海粉细砂的多组试验结果模拟,验证了本文模型的合理性和有效性。
语种:
中文
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