作者机构:
[潘思安; 刘余; 袁菡钰; 李娟; 岳增辉; 汪少华; 薛晓] College of Acupuncture-Moxibustion, Tuina and Rehabilitation, Hunan University of CM, Changsha 410208, China;[薛晓] Department of TCM, First Affiliated Hospital of University of South China
作者机构:
[Xiong, Luo-jie] Hunan Univ Chinese Med, Coll Acupuncture Massage & Rehabil, Changsha 410208, Peoples R China.;[Tian, YF; Zhai, Chun-tao; Tian, Yue-feng; Li, Wei] Shanxi Univ Chinese Med, Clin Coll 2, Jinzhong 030619, Shanxi, Peoples R China.
通讯机构:
[Tian, YF ] S;Shanxi Univ Chinese Med, Clin Coll 2, Jinzhong 030619, Shanxi, Peoples R China.
关键词:
acupuncture and moxibustion;Chinese materia medica;immune checkpoint;autoimmune disease;tumor
摘要:
Immunotherapy targeting immune checkpoint molecules has emerged as a key approach in cancer treatment, representing the forefront of antitumor research. However, studies on immune checkpoint molecules have mainly focused on targeted therapies. Chinese medicine (CM) research as a complementary medicine has revealed that immune checkpoint molecules also undergo disease-specific changes in the context of autoimmune diseases. This review article presents a comprehensive analysis of CM studies on immune checkpoint molecules in the last 5 years, with a focus on their role in different diseases and treatment modalities. CM research predominantly utilizes oral administration of herbal plant extracts or acupuncture techniques, which stimulate the immune system by activating specific acupoints through temperature and needling. In this study, we analyzed the modulation and mechanisms of immune checkpoint molecules associated with different coinhibitory and costimulatory molecules, and reviewed the immune functions of related molecules and CM studies in treating autoimmune diseases and tumors. By summarizing the characteristics and research value of CM in regulating immune checkpoint molecules, this review aims to provide a useful reference for future studies in this field.
作者机构:
[许明] College of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China. 004588@hnucm.edu.cn;[艾坤; 李亚; 匡静之; 刘琼; 陈晓雯; 邓石峰; 展立芬] College of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China;[张泓] College of Acupuncture-moxibustion, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China. zh5381271@sina.com. LA - eng
作者机构:
[来奕恬; 刘密; 周竞颖; 任玲; 张国山] College of Acupuncture-moxibustion and Tuina & Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, China
作者机构:
[肖慧; 段文丽; 熊武] The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China;[张熙] Hunan Brain Hospital, Changsha, 410007, China;[杨莹; 谭梅鑫; 彭阿建; 梁文菲] Hunan University of Chinese Medicine, College of Integrated Traditional Chinese and Western Medicine, Changsha, 410208, China;[赵世情] Hunan University of Chinese Medicine, College of Acupuncture & Tuina and Rehabilitation, Changsha, 410208, China;[肖郁婷] Hunan Brain Hospital, Changsha, 410007, China, Hunan University of Chinese Medicine, College of Integrated Traditional Chinese and Western Medicine, Changsha, 410208, China
摘要:
目的:压力性尿失禁是一种非常常见的疾病,治疗方法多,但是缺乏远期疗效追踪。本研究旨在通过对女性轻中度压力性尿失禁患者盆底康复治疗后3年的随访结果进行回顾性研究,为该病的临床治疗提供更为有效的方案。方法:收集2017年1月...展开更多 目的:压力性尿失禁是一种非常常见的疾病,治疗方法多,但是缺乏远期疗效追踪。本研究旨在通过对女性轻中度压力性尿失禁患者盆底康复治疗后3年的随访结果进行回顾性研究,为该病的临床治疗提供更为有效的方案。方法:收集2017年1月至2019年1月在中南大学湘雅三医院盆底康复中心诊断为压力性尿失禁的279例女性患者的临床资料。所有患者均接受健康宣教并嘱回家每天坚持Kegel运动20 min。根据接受治疗情况分为3组:A组(n=94),接受盆底生物反馈+电刺激+电针治疗;B组(n=99),接受盆底生物反馈+电刺激治疗;C组(n=86),只进行盆底功能检查,未接受盆底治疗。盆底功能检查包括盆底电生理检测、盆腔脏器脱垂定量检查(pelvic organ prolapse quantitive examination,POP-Q)和压力性尿失禁严重程度评估。对所有患者在治疗前、治疗结束时及治疗结束后1、2、3年进行回访(共5次),随访内容包括国际尿失禁咨询委员会尿失禁问卷简表(ICIQ-UI Short Form,ICI-Q-SF)和尿失禁生活质量问卷(Incontinence Quality of Life,I-QOL)。接受治疗的患者中有43人返院,其中A组返院21人(A返院组),B组返院22人(B返院组),对2组进行盆底电生理检测和POP-Q。结果:问卷调查结果表明:治疗结束时及治疗后1、2、3年患者的漏尿率均是A组<B组<C组(均P<0.05),其漏尿复发率在治疗后2至3年趋于稳定;A组治疗后的I-QOL评分与B组差异无统计学意义(P>0.05),但均高于C组(均P<0.05);治疗结束时及治疗后1、2、3年ICI-Q-SF评分均是A组<B组<C组(均P<0.05);产次对治疗后I-QOL和ICI-Q-SF评分及漏尿率有显著影响(P<0.05)。返院再次评估结果表明:A返院组和B返院组治疗结束时阴道前壁(Aa点)脱垂程度的差异无统计学意义(P>0.05),但是治疗后3年小于B返院组(P<0.05);A返院组和B返院组治疗结束时盆底肌力差异无统计学意义(P>0.05),但是治疗后3年大于B返院组(P<0.05);A返院组治疗结束时和治疗后3年肌电位均高于B返院组(均P<0.05)。结论:盆底生物反馈+电刺激+电针治疗相较于盆底生物反馈+电刺激治疗女性压力性尿失禁的近期疗效更显著、远期疗效更稳定,且能明显提高女性生活质量。收起
作者机构:
[Si-An Pan; Zhi-Miao Murong; Yi-Lin Zhu; Jia-Wei Song; Xiao-Rong Chang; Yu Liu; Zeng-Hui Yue] Department of Professional Acupuncture and Moxibustion, College of Acupuncture, Moxibustion and Tuina, Hunan University of Chinese Medicine
摘要:
Based on extensive historical data, clinical experience, and modern scientific research, we discuss the relationship between meridians and viscera of decreased ovarian reserve(OR) from the perspective of “preventive treatment of disease” by acupuncture. It is believed that the endogenous protection mechanism of acupuncture in “preventive treatment of disease” lies in harmonizing Yin and Yang and dredging meridians; stimulating righteousness and rejecting the evil outside; preventing disease; co-cultivating body and spirit, and regulating emotions. The incidence of OR dysfunction is closely related to the uterus-related meridians and viscera. The mechanism of acupuncture treatment of OR dysfunction may be related to reproductive endocrine hormone levels, ovarian tissue morphology, immune system, granulosa cell apoptosis, and related signal transduction pathways. The clinical effect of acupuncture treatment of diminished OR is reflected in improving menstruation and ovulation;improving OR function, promoting pregnancy; improving local ovarian microenvironment; improving negative emotions, improving quality of life, and thus affecting pregnancy outcomes. This article summarizes the mechanism of action and clinical effect of acupuncture in the treatment of decreased OR function based on recent findings, analyzes the advantages and disadvantages of acupuncture in the treatment of disease, and provides the rationale for the clinical application of acupuncture in the treatment of decreased OR function.
作者:
Li-Hong Fan;Wu Wei;Hui-Rong Wang;Xiao-Rong Chang;Li-Juan Yi
期刊:
African Journal of Business Management,2023年17(6):106-119 ISSN:1993-8233
作者机构:
[Wu Wei] Department of Cardiology, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.;[Xiao-Rong Chang] College of Acu-moxibustion and Massage, Hunan University of Chinese Medicine, Changsha, China.;[Li-Juan Yi] Nursing Department, Hunan Traditional Chinese Medical College, Zhu zhou, China.;[Li-Hong Fan; Hui-Rong Wang] Nursing Department, Changsha Social Work College, Changsha, China.
摘要:
We proposed to identify the general situation and trends in the field of job embeddedness (JE) and affective commitment (AC), given the essential role and association between them. Relevant literature was obtained from the Web of Science Core Collection on December 30, 2022. VOSviewer and CiteSpace were used for bibliometric analysis of authors, countries, institutions, journals, co-citation and keywords. A total of 315 literatures were retrieved ultimately. The quantity of literature and citations showed an overall rising trend from 1998 to 2022, with three fluctuations in 2008, 2013 and 2019. The USA was the leading driving force in the research. The collaborative network highlighted that countries, institutions and academic teams had not collaborated enough. Keyword analysis revealed that the mediating role of JE in turnover intention, especially from a psychology and organizational behavior perspective, is a highly discussed topic, with nurses and hotel workers as the main research targets. Research on JE and AC has flourished, but more theoretical and empirical studies should be conducted to further explore this domain. Emphasis should be placed on employee psychology and organizational behavior in future research.