作者机构：
[Liu, Yanfei; Hu, Yaqin; Wen, Nachuan; Wang, Ying] Cent S Univ, Coll Chem & Chem Engn, Dept Pharmaceut Engn, Changsha 410083, Hunan, Peoples R China.;[Liu, Zhenbao; Cai, Shundong; He, Qunye; Yan, Jianhua; Xiong, Hongjie] Cent S Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmaceut, Changsha 410013, Hunan, Peoples R China.;[Peng, Dongming] Hunan Univ Chinese Med, Sch Pharm, Dept Med Chem, Changsha 410208, Hunan, Peoples R China.
通讯机构：
[Liu, Yanfei; Liu, Zhenbao] C;Cent S Univ, Coll Chem & Chem Engn, Dept Pharmaceut Engn, Changsha 410083, Hunan, Peoples R China.;Cent S Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmaceut, Changsha 410013, Hunan, Peoples R China.
关键词：
Drug delivery system;Drug release mechanism;Metal-organic framework;Stimuli-responsive
摘要：
Metal-organic framework (MOF), a novel hybrid porous material which is composited by metal ions and organic linkers, has drawn increasing attention and became a promising material in the biomedical field owing to their unique properties including large pore volume, high surface area, tunable pore size, versatile functionality and high drug loading efficiency. However, the MOF families and members, and the drug release mechanisms in MOF-based stimuli-responsive drug delivery systems (DDSs) are rarely summarized. Here, we systematically classified the families of MOF and introduced some representative members in MOF families. Moreover, the underlying drug release mechanisms were interpreted according to endogenous stimuli (include pH, glutathione (GSH), adenosine-triphosphate (ATP), ion, glucose, enzyme, H2S, and etc.) and the exogenous stimuli (include light, temperature, pressure, and etc.). Furthermore, the remaining challenges and future directions of DDSs based on MOF are discussed and proposed. This review revealed the relationship between the structure and properties of MOF. A better understanding of these release mechanisms under different stimuli would benefit the designing of sophisticated DDSs based on the promising material of MOF.
期刊：
Journal of the American Chemical Society,2019年141(2):1126-1134 ISSN：0002-7863
通讯作者：
Feng, Lei;Ma, Xiaochi
作者机构：
[Yu, Zhenlong; Tian, Xiangge; Dong, Peipei; Sun, Chengpeng; Ning, Jing; Wang, Bo; Huo, Xiaokui; Wang, Chao; Feng, Lei; Ma, Xiaochi; Shi, Lei] Dalian Med Univ, Coll Pharm, Natl & Local Joint Engn Res Ctr Drug Dev Neurodeg, Coll Integrat Med, Dalian 116044, Peoples R China.;[Ning, Jing; Liu, Tao; Cui, Jingnan; Feng, Lei] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China.;[Wang, Wei] Hunan Univ Chinese Med, Sch Pharm, Sino Pakistan TCM & Ethnomed Res Ctr 8, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Hunan, Peoples R China.;[Ge, Guangbo] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai 201203, Peoples R China.;[James, Tony D.] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England.
通讯机构：
[Feng, L; Ma, XC; Feng, Lei] D;Dalian Med Univ, Coll Pharm, Natl & Local Joint Engn Res Ctr Drug Dev Neurodeg, Coll Integrat Med, Dalian 116044, Peoples R China.;Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China.
摘要：
Except for an essential step for the pathology of multiple diseases including atherosclerosis and rheumatoid arthritis, inflammation is an imperative therapeutic target for developing novel approaches for pharmacological interventions. Thus, molecular understanding of inflammation not only revealed the mechanisms of drug action and their biological targets but also has spawned innovative maneuvers to influence multifaceted biological systems, providing new prospects for drug designing and suggesting important new implications for existing clinical medicine. Meanwhile, modulation of inflammation with the use of medicinal plants proposed an alternate to conventional therapeutic strategies for numerous ailments, particularly when suppression of inflammation is expected. In modern literature, several species of medicinal plants have been shown substantial antiinflammatory and immunomodulatory actions including inhibitory effects on suppression of cellular and humoral immunity, lymphocyte activation, and propagation of apoptosis. Herein, we reviewed the molecular pharmacology of inflammation, chemical components and biological activities of medicinal plants such as, curcumin from Curcuma longa, and epigallocatechin-3-gallate from Camellia sinensis as well as their mechanism of action during inflammation at molecular level. An extensive review of the literature and electronic databases was conducted, encompassing PubMed, GoogleScholar, ScienceDirect, medlineplus, www.clinicaltrial.gov, www.fda.gov, www.ema.europa.eu, www.drugbank.ca, TrialBulletin.com, www.theplantlist.org, and www.pharmacodia.com for assembling the information. Additionally, data was attained from books, ethnopharmacological literature, and relevant publications for essential elements of molecular mechanisms, signal transduction networks, transcription factors, complement system, reactive species, and clinical trials are selected for substantial understanding of biochemistry, pathophysiology as well as clinical importance of medicinal plants during inflammatory diseases.
摘要：
Parkinson's disease (PD) is a typical neurodegenerative disease and the pathological feature of which is the death of dopamine neurons in the substantia nigra region. At present, neuronal death caused by inflammatory cytokine-mediated neuroinflammation is being extensively studied. The nucleotide-binding oligomerization domain-, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome is an inflammatory complex existing in microglia. Its activation promotes the secretion of the inflammatory cytokine interleukin-1beta/18 (IL-1beta/18) and induces pyroptosis, a type of cell death that possesses the potential for inflammation, to rupture microglia to further release IL-1beta. In this review we focus on the mechanisms of activation of the NLRP3 inflammasome and pyroptosis and their inflammatory effects on the development of PD. In addition, we focus on some inhibitors of NLRP3 inflammatory pathways to alleviate the progression of PD by inhibiting central inflammation and provide new therapeutic strategies for the treatment of PD.
摘要：
The disorder of lipid metabolism is pathologically linked to hyperlipidemia, lipid storage disease, obesity and other related diseases. Intriguingly, recent studies have revealed that lipid metabolism disorders play an important role in carcinogenesis and development as well, since they cause abnormal expression of various genes, proteins, and dysregulation of cytokines and signaling pathways. More importantly, lipid-lowering drugs and anti-lipid per-oxidation treatment have been showing their advantages in clinic, in comparison with other anti-cancer drugs with high toxicity. Thus, further elucidation of molecular mechanism between lipid metabolism and cancer is essential in developing novel diagnostic biomarkers and therapeutic targets of human cancers.
