Progress on nanomaterials based-signal amplification strategies for the detection of zearalenone
作者：
Liao, Zhibing;Yao, Liu;Liu, Yan;Wu, Yaohui;Wang, Yonghong;...
期刊：
Biosensors and Bioelectronics: X ,2021年9:100084 ISSN：2590-1370
通讯作者：
Wang, Yonghong(bionano@163.com);Ning, Ge(37099876@qq.com)
作者机构：
[Liao, Zhibing; Yao, Liu; Liu, Yan; Wu, Yaohui; Wang, Yonghong] Hunan Provincial Key Laboratory for Forestry Biotechnology & International Cooperation Base of Science and Technology Innovation on Forest Resource Biotechnology, Central South University of Forestry and Technology, Changsha;410004, China;[Ning, Ge] International Education Institute, Hunan University of Chinese Medicine, Changsha;410208, China;[Liao, Zhibing; Yao, Liu; Liu, Yan; Wu, Yaohui; Wang, Yonghong] 410004, China
通讯机构：
[Yonghong Wang] H;[Ge Ning] I;Hunan Provincial Key Laboratory for Forestry Biotechnology & International Cooperation Base of Science and Technology Innovation on Forest Resource Biotechnology, Central South University of Forestry and Technology, 410004, Changsha, China<&wdkj&>International Education Institute, Hunan University of Chinese Medicine, 410208, Changsha, China
关键词：
Concentrator;Nanocarrier;Nanomaterials;Signal amplification;Support platform;Transducer;Zearalenone
摘要：
Zearalenone (ZEN) was a toxic compound secreted by the metabolism of fungi that exerted negative influence over human and animal health due to its carcinogenicity, mutagenicity, genotoxicity, nephrotoxicity, immunotoxicity and teratogenicity. The superiority of biosensors was recognized which held a great potential for ZEN detection because they were less costly and much friendlier in preparation and operation steps but further sensitive, specific, rapid, and portable. This review was designed to pose a comprehensive interpretation on ZEN detected biosensors through highlighting the nanomaterials for fabricating the sensing elements and their applications in assorted read-out types of biosensors. Besides, novel nanomaterials-based signal amplification strategies utilized to accomplish this goal were overviewed and analyzed in detail. Current challenges and future perspectives were discussed as well. © 2021 The Authors
语种：
英文
展开
A novel ratiometric electrochemical assay for ochratoxin A coupling Au nanoparticles decorated MoS2 nanosheets with aptamer
作者：
Wang, Yonghong;Ning, Ge;Bi, Hao;Wu, Yaohui;Liu, Gaoqiang* ;...
期刊：
Electrochimica Acta ,2018年285:120-127 ISSN：0013-4686
通讯作者：
Liu, Gaoqiang;Zhao, Yunlin
作者机构：
[Liu, Gaoqiang; Liu, GQ; Zhao, YL; Zhao, Yunlin; Wu, Yaohui; Bi, Hao; Wang, Yonghong] Cent South Univ Forestry & Technol, Coll Life Sci & Technol, Hunan Prov Key Lab Forestry Biotechnol, Changsha 410004, Hunan, Peoples R China.;[Ning, Ge] Hunan Univ Chinese Med, Int Educ Inst, Changsha 410208, Hunan, Peoples R China.
通讯机构：
[Liu, GQ; Zhao, YL] C;Cent South Univ Forestry & Technol, Coll Life Sci & Technol, Hunan Prov Key Lab Forestry Biotechnol, Changsha 410004, Hunan, Peoples R China.
关键词：
MoS2 nanosheets;Host-guest recognition;Aptamer;Ochratoxin A;Electrochemical
摘要：
A novel aptamer sensor for ratiometric ochratoxin A (OTA) detection was constructed based on the host-guest competition mode. Firstly, the aptamer modified with methylene blue (MB) at its terminal was fixed on the surface of the gold electrode via the host-guest recognition with β-cyclodextrin (β-CD). Then the MoS<inf>2</inf> nanosheets/Au NPs nanocomposites were used for the signal amplification. When OTA was present, the configuration of MB-aptamer transformed from vertical linear to G-quadruplex, thus making itself unable to get close to the electrode surface and causing a decrease in the redox current of the MB-aptamer. Whereas the free ferrocenecarboxylic acid could recognize and occupy the vacant site and produce signals in the current, resulting in the “ratiometric”effect. Consequently, on the basis of the “dual-signal”principle, a highly sensitive detection of OTA was made, indicating that the OTA concentration had a linear response to the signal of sensor between 0.1 nM and 50 nM, and as low as 0.06 nM OTA had been detected. Overall, this method for OTA detection was constructed easily with high sensitivity and specificity, providing a significant platform for highly efficient detection of OTA in biological samples.<br/> ©2018 Elsevier Ltd
语种：
英文
展开
