作者机构：
[刘梨; 龚志贤] The First Affiliated Hospital /The First Clinical College of Hunan University of Chinese Medicine, Changsha 410007, China;[张亮; 艾坤; 祁芳] College of Acupuncture-Moxibustion and Tuina, Hunan University of Chinese Medicine, Changsha 410208;[李鑫] Hunan Provincial Key Laboratory of Diagnostics of Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208;[王文怡; 徐美丽] College of Nursing, Hunan University of Chinese Medicine, Changsha 410208
作者机构：
[周雯; 张艳] Department of Clinical Nursing, The Second Xiangya Hospital of Central South University, Changsha, 410011, China;[晋溶辰; 陈偶英; 伍永慧] School of Nursing, Hunan University of Chinese Medicine, Changsha, 410208, China;[Qin F.] Department of Infectious Diseases, Hunan Children′s Hospital, Changsha, 410007, China
摘要：
Purpose: Music and animation are the most common and affordable distraction strategies to reduce preoperative anxiety in children; however, their effects are inconsistent. This study aimed to examine the effectiveness of two distraction strategies (music or animation) in reducing preoperative anxiety in children.Design and methods: In this randomized controlled trial, 183 children who underwent surgery were divided into music, animation, and control groups using a single-blind block randomized design. Children in the control group underwent routine preoperative visits. Meanwhile, the children in the intervention groups could choose their fa-vorite music and cartoons as intervention content. Study outcomes included anxiety levels, degree of coopera-tion, heart rate, and blood pressure. Data were collected before entering the operating room, entering the operating room, and before the induction of anesthesia; only the degree of cooperation was collected before the induction of anesthesia.Results: Only animation significantly reduced preoperative anxiety in the children (P < 0.05) upon entering the operating room. Both music and animation reduced the level of preoperative anxiety before induction of an-esthesia; however, there was no significant difference between them (P > 0.05). The induction compliance score was significantly lower in the music and animation groups than in the control group (P < 0.05). Heart rates differed significantly between the three groups from before entering the operating room to before induction of anesthesia. Children in the control group had the highest systolic blood pressure upon entering the operating room (P < 0.05).Conclusions: Music and animation strategies can significantly reduce preoperative anxiety in children and improve surgical cooperation during anesthesia induction.Trial Registration: Clinical.Trials.gov NCT05285995.(c) 2022 Elsevier Inc. All rights reserved.
期刊：
BMJ GLOBAL HEALTH,2023年8(8):e013502 ISSN：2059-7908
作者机构：
School of Nursing, Hunan University of Chinese Medicine, Changsha, Hunan, China;School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, kelantan, Malaysia;School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
作者：
Qin, L. -H.;Chen, L.;Cao, X.;Huang, T. -J.;Li, Z. -Y.;...
期刊：
European Review for Medical and Pharmacological Sciences,2023年27(14):6496-+ ISSN：1128-3602
通讯作者：
Qin, LH
作者机构：
[Li, Z. -Y.; Cao, X.; Qin, LH; Chen, L.; Qin, L. -H.; Huang, T. -J.] Hunan Univ Chinese Med, Sch Nursing, Changsha, Peoples R China.;[Li, S.; Qin, LH; Qin, L. -H.] Hunan Univ Chinese Med, Key Lab Hunan Prov Prevent & Treatment Integrated, Changsha, Peoples R China.;[Wang, G. -Z.] Hunan Univ Chinese Med, Clin Sch Chinese Med 2, Changsha, Peoples R China.
通讯机构：
[Qin, LH ] H;Hunan Univ Chinese Med, Sch Nursing, Changsha, Peoples R China.;Hunan Univ Chinese Med, Key Lab Hunan Prov Prevent & Treatment Integrated, Changsha, Peoples R China.
摘要：
- OBJECTIVE: The aim of this study was to identify sex-specific biomarkers for ischemic stroke (IS) prophylaxis in elderly individuals. MATERIALS AND METHODS: The GSE22255 dataset for elderly individuals with IS was retrieved from the gene expression omnibus database. Thereafter, gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed, as well as gene set enrichment analysis (GSEA). Furthermore, protein-protein interactions (PPIs) were explored using the STRING database, and to screen central genes from the Cytoscape PPI network, corresponding to peripheral blood samples from elderly individuals, we used the molecular complex detection plug-in and cytoHubba. Moreover, a Venn diagram was used to visualize the key genes common among elderly women and men with IS. Statistical analysis was also performed, and receiver operating characteristic (ROC) curves were constructed to evaluate the specificity and sensitivity of the prediction of IS in the elderly. RESULTS: Compared with the healthy controls, in elderly women with IS, 511 biological process (BP) terms, 16 molecular function (MF) terms, and 34 KEGG terms were significantly enriched, whereas in the elderly men with IS, 681 BP terms, 12 MF terms, and 44 KEGG terms were enriched. The GSEA revealed 99 and 140 significantly enriched gene sets in elderly women and men with IS, respectively. Furthermore, in the PPI network, 10 hub genes for each sex with high specificity and sensitivity were identified using ROC curves. CONCLUSIONS: Ten genes for each sex with significant differential expression were also identified in individuals with IS. The novel sex-specific gene targets may be promising diagnostic or prognostic markers and potential therapeutic targets for IS in the elderly.
摘要：
目的应用可视化方法分析近30年国内外宫颈癌中医药领域研究热点及趋势。方法以“宫颈癌”“中医药”等为研究主题,检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)、中国生物医学文...展开更多 目的应用可视化方法分析近30年国内外宫颈癌中医药领域研究热点及趋势。方法以“宫颈癌”“中医药”等为研究主题,检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science核心数据库(WoS)1992年1月1日-2022年1月1日宫颈癌中医药领域研究文献,采用CiteSpace 5.8.R3软件对纳入文献的作者、机构、关键词进行可视化分析。结果共纳入中文文献1123篇、英文文献573篇,发文量呈逐渐上升趋势。中文发文量最多的作者是金哲,英文发文量最多的作者是CHEN GUO;中文发文量最多的机构是北京中医药大学;英文发文量最多的机构是Chinese Academy of Med Sciences(中国医学科学院)。关键词共现网络频次排名前3位(去除检索词)的中文关键词为“宫颈糜烂”“尿潴留”“云南白药”;英文关键词为“hela cell”“bibliometric”“information monitoring system”。中文关键词形成11个聚类,25个突现词;英文关键词形成9个聚类,17个突现词。结论近30年国内外宫颈癌中医药领域研究内容丰富,中医药可发挥拮抗人乳头瘤病毒、增强免疫功能及调节中医体质、提升生活质量等作用,目前研究热点为宫颈癌机制探究及并发症疗效研究,研究趋势为临床疗效研究。收起
摘要：
目的探讨基于中医情志护理的持续沟通联合耳穴压豆在精神分裂症患者中的护理效果。方法选择2020年1月至2021年12月在长沙市某三甲医院收治的精神分裂症患者98例,随机分为观察组和对照组,各49例。两组患者均予以奥氮平片,...展开更多 目的探讨基于中医情志护理的持续沟通联合耳穴压豆在精神分裂症患者中的护理效果。方法选择2020年1月至2021年12月在长沙市某三甲医院收治的精神分裂症患者98例,随机分为观察组和对照组,各49例。两组患者均予以奥氮平片,5~20 mg/d,1次/d,对照组行常规心理疏导及健康宣教,观察组给予基于中医情志护理的持续沟通联合耳穴压豆,两组疗程均为8周。采用精神病评估量表(brief psychiatric rating scale,BPRS)评估两组患者精神病症状、社会功能评定量表(scale of social function of psychosis inpatients,SSFPI)评估社会功能改善情况、住院病人观察量表(nurses'observation scale for inpatient evaluation,NOSIE)评估行为障碍程度,并记录危险发生情况,比较两组患者护理效果。结果干预后,观察组BPRS评分低于对照组,差异有统计学意义(P<0.05);观察组SSFPI评分、NOSIE积极方面评分均高于对照组,差异有统计学意义(P<0.05);观察组NOSIE量表消极方面评分及危险行为发生率均低于对照组,差异有统计学意义(P<0.05)。结论基于中医情志护理的持续沟通联合耳穴压豆可有效改善精神分裂症患者的精神症状、社会功能及行为障碍,并降低其危险行为发生率,值得临床推广应用。收起
