作者机构：
College of Integrated Medicine, Hunan University of Chinese Medicine, Changsha, 410208;College of Acupuncture & Tuina, Hunan University of Chinese Medicine, Changsha, 410208;[曹淼; 张林; 何清湖] College of Integrated Medicine, Hunan University of Chinese Medicine, Changsha, 410208;[贲定严] College of Acupuncture & Tuina, Hunan University of Chinese Medicine, Changsha, 410208
通讯机构：
[Qing-hu He] C;College of Integrated Medicine, Hunan University of Chinese Medicine, Changsha, China
摘要：
Objective: To explore the points selection pattern of acupuncture for sleep apnea syndromes by data mining technique. Methods: Clinical literature about acupuncture therapy for sleep apnea syndromes was derived from China National Knowledge Infrastructure (CNKI), Wanfang Academic Journal Full-text Database (Wanfang), Chongqing VIP Database (CQVIP), PubMed and Science Direct between the time that databases were created and March 25th,2017. Relevant excel database was established and descriptive studies and association rules were analyzed. Results: The most frequently used point was Lianquan (CV 23) and the most frequently used meridian was the Stomach Meridian. The analysis of association rules showed that the clinical choice of acupuncture points was highly correlated, among which the combination of the highest degree of confidence and the highest degree of support was Shenmen (HT 7) and Sishencong (EX-HN 1); Lieque (LU 7), lianquan (CV 23) and Zhaohai (KI 6). Conclusion: Acupuncture treatment of sleep apnea syndromes has specific selection rules of points, providing certain references for clinical and scientific research.
作者：
Cao Miao;Deng Fang-fang;Yuan Qun;Zhang Ji-dong;He Qing-hu;...
期刊：
针灸推拿医学：英文版,2018年16(4):236-242 ISSN：1672-3597
通讯作者：
Qing-hu He
作者机构：
Hunan University of Chinese Medicine, Changsha, 410208;The First Hospital of Hunan University of Chinese Medicine, Changsha, 410021;Institute of Basic Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700;[Cao Miao; Yuan Qun; He Qing-hu] Hunan University of Chinese Medicine, Changsha, 410208;[Deng Fang-fang] The First Hospital of Hunan University of Chinese Medicine, Changsha, 410021
通讯机构：
[Qing-hu He] H;Hunan University of Chinese Medicine, Changsha, China
摘要：
Objective: To systematically evaluate the therapeutic efficacy of tuina therapy for primary insomnia. Methods: Nine Chinese and English databases were searched from the inception to May 2017 to identify randomized controlled trials (RCTs) studying tuina therapy for insomnia. The enrolled articles were all RCTs with tuina as the monotherapy or major therapy in the experiment group, with clear diagnostic criteria for primary insomnia well recognized worldwide or in China, and Pittsburgh sleep quality index (PSQI) as one of the outcome measures. Two researchers evaluated the risk of bias and quality of the enrolled studies by following Cochrane Handbook version 5.1.0. The meta-analysis was performed by RevMan version 5.3. Results: Eleven studies were included with a total of 1 076 participants. The Western medication adopted in the control groups were benzodiazepine receptor agonists. The studies were all assessed as high risk of bias for blinding since blinding method was unable to be performed due to the specificity of tuina therapy; no study reported the support of fund or potential interest conflict, so they were all rated unclear for selective reporting. The meta-analysis showed that compared with other traditional Chinese medicine therapies, tuina worked more effectively in reducing the PSQI score (MD=-4.11<0, 95% confidence interval (CI) -6.01 to -2.22, P<0.0001); compared with oral administration of Western medication, tuina showed more significant efficacy in reducing the PSQI score (MD=-3.42<0, 95%CI -5.19 to -1.66, P<0.0001). Subgroup analysis showed that head tuina alone showed no significant difference compared with oral administration of Western medication regarding the change of PSQI score (MD=-4.19<0, 95%CI -8.87 to 0.50, P>0.05); a combination of head and back tuina could more effectively reduce the PSQI score compared with oral administration of Western medication (MD=-2.08<0, 95%CI -3.09 to -1.06, P<0.0001). Conclusion: Tuina can produce more significant efficacy in treating primary insomnia compared with other traditional Chinese medicine therapies and oral administration of Western medication, especially the combination of head and back tuina.
摘要：
目的:研究知柏地黄汤对解脲脲原体(U U)感染模型大鼠精子线粒体膜电位(M M P)、活性氧(ROS)水平及细胞色素C(CytC)含量的影响.方法:雄性SD大鼠80只,随机分成假手术组、模型组、中药组(知柏地黄汤,2mL/d)、中西组(知柏地黄汤+强力霉素)、西药组(强力霉素,2mL/d),除假手术组外,其他组均采用经大鼠膀胱注射UU建立UU感染动物模型.连续灌胃给药21d后处死取标本检测,采用荧光流式细胞技术(JC-1染色)测定精子MMP水平(JC-1+%)及ROS水平(JC-1+%),采用ELISA法检测CytC含量.结果:模型组大鼠精子MMP(JC-1+%)、ROS水平(JC-1+%)及精子中CytC含量,与假手术组比较,差异显著(P<0.01);各治疗组中精子MMP水平上升,ROS水平、CytC含量下降,其中,中西组与模型组比较,差异显著(P<0.01).结论:知柏地黄汤能够提高UU感染大鼠精子MMP水平,减少精子ROS产生,减少精子凋亡,抑制CytC释放,这可能是知柏地黄汤治疗UU感染所致男性不育症的机制之一.
