Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer

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成果类型：

期刊论文

作者：

Wang, Zhiqi;Li, Sai;Cao, Yu;Tian, Xuefei;Zeng, Rong;...

通讯作者：

Cao, Deliang

作者机构：

[Tian, Xuefei; Wang, Zhiqi; Li, Sai; Liao, Duan-Fang; Cao, Deliang; Zeng, Rong] Hunan Univ Chinese Med, Dept Pharmacol, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha 410208, Hunan, Peoples R China.

[Tian, Xuefei; Wang, Zhiqi; Li, Sai; Liao, Duan-Fang; Cao, Deliang; Zeng, Rong] Hunan Univ Chinese Med, Key Lab Coll, Changsha 410208, Hunan, Peoples R China.

[Tian, Xuefei; Wang, Zhiqi; Li, Sai; Liao, Duan-Fang; Cao, Deliang; Zeng, Rong] Hunan Univ Chinese Med, Univ Hunan Prov Cytobiol & Mol Biotechnol, Changsha 410208, Hunan, Peoples R China.

[Cao, Yu; Cao, Deliang] So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, 913 N Rutledge St, Springfield, IL 62794 USA.

通讯机构：

[Cao, Deliang] H

[Cao, Deliang] S

Hunan Univ Chinese Med, Dept Pharmacol, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Key Lab Coll, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Univ Hunan Prov Cytobiol & Mol Biotechnol, Changsha 410208, Hunan, Peoples R China.

语种：

英文

期刊：

Oxidative Medicine and Cellular Longevity

ISSN：

1942-0900

年：

2016

卷：

2016

页码：

9875298

DOI：

10.1155/2016/9875298

基金类别：

Hunan Engineering Center for Rapid Test and Removal of Toxic and Harmful Substances in Chinese Medicine [201303]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81503492, 81272918, 81472465]

机构署名：

本校为第一且通讯机构

院系归属：

中西医结合学院

药学院

摘要：

Oxidative stress has long been known as a pathogenic factor of ulcerative colitis (UC) and colitis-associated colorectal cancer (CAC), but the effects of secondary carbonyl lesions receive less emphasis. In inflammatory conditions, reactive oxygen species (ROS), such as superoxide anion free radical (O 2 -), hydrogen peroxide (H2O2), and hydroxyl radical (H O ), are produced at high levels and accumulated to cause oxidative stress (OS). In oxidative status, accumulated ROS can cause protein dysfunction and DNA damage, leading to gene mutations and cell death. Accumulated ROS could also act as ...

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Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer

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