Circadian clock: a regulator of the immunity in cancer

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Zhen;Zeng, Puhua;Gao, Wenhui;Zhou, Qing;Feng, Ting;...

通讯作者：

Tian, Xuefei

作者机构：

[Tian, Xuefei; Zhang, Zhen; Feng, Ting] Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Dept Internal Med, 300 Xueshi Rd, Changsha 410007, Hunan, Peoples R China.

[Tian, Xuefei; Gao, Wenhui; Zhang, Zhen; Feng, Ting] Hunan Univ Chinese Med, Hunan Key Lab TCM Prescript & Syndromes Translat, Changsha 410208, Peoples R China.

[Zeng, Puhua] Hunan Acad Tradit Chinese Med, Affiliated Hosp, Changsha 410006, Peoples R China.

[Zhou, Qing] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Androl, Changsha 410208, Peoples R China.

通讯机构：

[Tian, Xuefei] H

Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Dept Internal Med, 300 Xueshi Rd, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

Circadian clock;Cancer;Cancer-immunity cycle;Chrono-immunotherapies;Tumor microenvironment (TME)

期刊：

Cell Communication and Signaling

ISSN：

1478-811X

年：

2021

卷：

期：

页码：

1-12

DOI：

10.1186/s12964-021-00721-2

基金类别：

The authors gratefully acknowledge the financial support from the Key projects supported by National Natural Science Foundation of China U20A20408), National Natural Sciences Foundation of China (82074450), Natural Science Foundation of Hunan Province (2020JJ4066); Postgraduate innovation project of Hunan University of Chinese Medicine in 2020 (2020CX88, 2020CX14), “YIFANG” Postgraduate Innovation Project of Hunan University of Chinese Medicine (2020YF04, 2020YF03).

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

中西医结合学院

摘要：

The circadian clock is an endogenous timekeeper system that controls and optimizes biological processes, which are consistent with a master circadian clock and peripheral clocks and are controlled by various genes. Notably, the disruption of circadian clock genes has been identified to affect a wide range of ailments, including cancers. The cancer-immunity cycle is composed of seven major steps, namely cancer cell antigen release and presentation, priming and activation of effector immunity cells, trafficking, and infiltration of immunity to tumors, and elimination of cancer cells. Existing ev...

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