期刊论文

中文

长春中医药大学学报

2095-6258

2013

29

1

10-13

10.3969/j.issn.1007-4813.2013.01.005

国家自然科学基金课题资助（编号：30973802） 湖南省科技计划项目（2011SK3095） 湖南省中医药科研计划课题（2010101） 长沙市科技计划重点项目（K1005020.31）.

本校为第一机构

目的:观察隔艾炷灸对兔动脉粥样硬化(artherosclerosis,AS)中基质金属蛋白酶-2、9(matrix metalloproteinases,MMP-2、9)表达的影响,探讨艾炷灸对兔动脉粥样硬化斑块稳定性的影响.方法:60只新西兰大耳白兔,随机分为空白组(空白对照组)、模型组(AS模型组)、艾炷灸组(AS模型加艾炷直接灸)和西药组(AS模型加阿托伐他汀),每组15只,除空白组外,其余3组通过高脂饲料喂养及免疫损伤法建立兔AS模型.运用原位杂交法检测兔动脉粥样硬化斑块中MMP-2和MMP-9 mRNA的表达.结果:与模型组相比,艾炷灸组和西药组AS斑块中MMP-9 mRNA的表达差异有统计学意义(P＜0.05,P＜0.01)；西药组AS斑块中MMP-2 mRNA的表达差异有...

Object： To observe the effect of direct moxibustion to mRNA expression of matrix metalloproteinases-2,9 （MMP-2, MMP-9）in artherosclerosis （AS） plaques of rabbits, to explore the effect of direct moxibustion to the stability of artherosclerosis plaques of rabbits. Method： 60 New Zealand rabbits were randomly allocated to blank, model, direct moxi- bustion, western medicine groups. 15 cases in each group. Expect blank group, the other groups were feeded by high-fat diet. The mRNA expression of MMP-2, MMP-9 in the atherosclerotic plaques of ...