Construct a lysosome-targeting and highly selective fluorescent probe for imaging of hydrogen sulfide in living cells and inflamed tissues

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成果类型：

期刊论文

作者：

Wan, Dan;Pan, Tao;Ou, Pinghua*;Zhou, Rongrong*;Ouyang, Ziting;...

通讯作者：

Peng, Yongbo;Zhou, Rongrong;Ou, Pinghua

作者机构：

[Peng, Yongbo; Wan, Dan; Pan, Tao] Hunan Acad Tradit Chinese Med, Inst Chinese Med, Changsha 410208, Peoples R China.

[Peng, Yongbo; Wan, Dan; Pan, Tao] Hunan Univ Tradit Chinese Med, Changsha 410208, Peoples R China.

[Peng, Yongbo; Zhou, Rongrong] Guangdong Pharmaceut Univ, Sch Clin Pharm, Affiliated Hosp 1, Guangzhou 510006, Peoples R China.

[Ou, Pinghua] Cent South Univ, Xiangya Hosp 3, Dept Stomatol, Changsha 410013, Peoples R China.

[Luo, Lan; Pan, Tao; Xiao, Zuoqi; Ouyang, Ziting] Hunan Prov Maternal & Child Hlth Care Hosp, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Peng, Yongbo] H

[Zhou, Rongrong] G

[Ou, Pinghua] C

Hunan Acad Tradit Chinese Med, Inst Chinese Med, Changsha 410208, Peoples R China.

Hunan Univ Tradit Chinese Med, Changsha 410208, Peoples R China.

语种：

英文

关键词：

Gas signaling molecule;Hydrogen sulfide;Inflammation tissue;Lysosome-targeting

期刊：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

ISSN：

1386-1425

年：

2021

卷：

249

页码：

119311

DOI：

10.1016/j.saa.2020.119311

基金类别：

Key Research and Development Project of Hunan Province [2019NK2101]; Hunan Province Administration of Traditional Chinese Medicine [201713]; Qian Ping Inheritance Studio of National and Old TCM Experts [T20194828003]

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

摘要：

Since the fluctuation of cellular hydrogen sulfide (H2S) is a very important third endogenously generated gaseous signaling molecule and plays a key role in the development of numerous human disorders, the real-time fluorescence detection of H2S in living systems has attracted plenty of interest during past decade. Although a lot of H2S fluorescent probes have been reported, the relationship between the physiology and pathology of H2S in organelles remains unclear, especially for inflammatory tissue. In this work, by adopting a weakly basic morpholine group as the lysosome-targeting site, a na...

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Construct a lysosome-targeting and highly selective fluorescent probe for imaging of hydrogen sulfide in living cells and inflamed tissues

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