期刊论文

中文

中国中医基础医学杂志

1006-3250

2004

10

4

66-68

10.3969/j.issn.1006-3250.2004.04.031

国家中医药管理局资助项目 （980 2 0 ）； 湖南省自然科学基金资助项目 （OOJJY10 0 6）；

本校为第一机构

目的:探讨针刺内关抗心肌缺血再灌注损伤的作用机理.方法:健康家兔50只随机分为假手术组、缺血再灌注模型组、缺血预处理组、电针内关组、电针足三里组5组,结扎家兔冠脉左前降支造成心肌缺血模型,观察血清肌酸激酶(CK)、心肌组织超氧化物歧化酶(SOD) 、谷胱甘肽过氧化物酶(GSH-px)及丙二醛(MDA)活性,用高效液相色谱法检测家兔心肌组织 ATP含量.结果:在缺血再灌注40min后,模型组心肌组织中SOD、GSH-px、ATP含量明显降低,CK及MDA含量明显升高,而缺血处理组、电针内关组可拮抗SOD、GSH-px、ATP降低和抑制CK、MDA升高,与模型组比较P

Method:50 healthy rabbits were randomly divided into 5 groups:control group, ZIR group, IP group. EA at Neigran group, EA at Zusunli group. The ischemia model was made by ligaturing the left anterior descending branch of coronary artery. The changes of creatine kinase(CK) and superoxide dismutase(SOD), glutathione peroxidase(GSH-px) as well as malondialdehyde(MDA) in myocardium were detected. The contents of Adenosino Pretreatment (ATP) in myocareium was examined by high performance liquid chromatograpy (HPLC). Results:In the I/R model group, the contents of SOD and GSH-px as well as ATP on my...