期刊论文

Effect of Tongxieyaofang on gastrointestinal hormone of diarrhea-predominant irritable bowel syndrome rats

中文

中国当代医药

1674-4721

2010

17

3

20-22

10.3969/j.issn.1674-4721.2010.03.009

本校为第一机构

目的:观察痛泻要方（TXYF）对腹泻型肠易激综合征（D-IBS）大鼠模型组织和血浆中胰高血糖样素肽（GLP-1）、生长抑素（SS）、P物质（SP）含量的影响,探讨其调节相关胃肠激素水平的作用机制。方法:采用灌胃番泻叶及束缚应激建立D-IBS大鼠模型,实验设空白对照组、模型组、匹维溴铵组、TXYF高剂量组、TXYF中剂量组、TXYF低剂量组。经灌胃给药或给生理盐水后,检测粪便干湿重,组织和血浆中GLP-1、SS、SP含量。结果:TXYF各治疗组除TXYF低剂量组外,大鼠粪便含水量均明显减少;组织和血液中GLP-1、SS、SP水平明显下降。结论:痛泻要方能抑制D-IBS大鼠GLP-1、SS、SP的分泌,TXYF高剂量组效果优于匹维溴铵组,...

Objective：To observing Tongxieyaofang （TXYF） on wet and dry stool weight of rats which suffering from Diarrhea-predominant irritable bowel syndrome （D-IBS） and levels of GLP-1, SS and SP in tissue and serum. Methods： Used gavage senna and restraint stress to establish D-IBS rat model.Set up normal contrast group, model group, pinaverium bromide group, TXYF high-dose group,TXYF middle -dose group, TXYF low-dose group. After gavaged drug or normal saline, detected of stool wet and dry weight and levels of GLP-1, SS and SP in tissue and seru...