期刊论文

中文

中国当代医药

1674-4721

2023

30

35

16-20+197

10.3969/j.issn.1674-4721.2023.35.005

本校为第一机构

目的 基于网络药理学和分子对接探讨丹酚酸B治疗对皮瓣缺血再灌注（I/R）损伤的作用机制。方法 依托swiss target predictiont、Super Pred数据库筛选丹酚酸B的作用靶点，并结合Uniprot数据库筛选药物有效靶点。利用Gene Cards、TTD、OMIM数据库检索与皮瓣I/R相关靶点，进而获得丹酚酸B和皮瓣I/R的交集靶点，将药物-交集基因上传至相互作用数据库String进行蛋白相互作用网络构建（PPI），通过David数据库对丹酚酸B防治皮瓣I/R的潜在靶点进行GO和KEGG通路富集分析，将筛选得到的核心靶点运用CB dock对关键靶点与相应活性成分进行分子对接验证。结果 筛选得到丹酚酸B治疗皮瓣I/R的潜在靶点39个，其...

Objective To explore the mechanism of salvianolic acid B in the treatment of flap ischemia/reperfusion(I/R)in-jury based on network pharmacology and molecular docking.Methods The action targets of salvianolic acid B were screened based on swiss target predictiont and SuperPred database,and the effective drug targets were screened in combination with Uniprot database.GeneCards,TTD and OMIM databases were used to search the targets related to flap I/R,and then the in-tersection targets of salvianolic acid B and flap I/R were obtained,and the drug-intersection genes were uploaded to the in-teract...