期刊论文

中文

中医药信息

1002-2406

2014

3

102-106

No．2010ZX09101-103:重大新药创制"科技重大专项(十一五) No．10C728:湖南省教育厅项目 2007:湖南中医药大学中医基础理论重点学科建设项目

本校为第一机构

目的：观察降脂消斑片对VEGF介导的AS斑块中炎症反应的影响。方法：运用高脂高胆固醇饲料喂养12周造成日本大耳白兔动脉粥样硬化模型，用降脂消斑片灌胃给药治疗4周，采用双抗体夹心酶联免疫吸附法检测血清中 ICAM -1、MMP -9的含量；采用免疫组化法分析 VEGF、ICAM -1、MMP-9在主动脉粥样斑块中的表达量。结果：与模型组比较，降脂消斑片能明显降低血清中ICAM-1、MMP-9的含量，差异均具有统计学意义（ P＜0．01）；同时也能明显降低VEGF、ICAM-1、MMP-9在主动脉粥样斑块中的面密度，差异均具有统计学意义（ P＜0．01）。结论：降脂消斑片抑制AS斑块内VEGF的表达，进而降低AS斑块中ICAM-1、MMP-...

Objective:To observe the effects of Jiangzhi Xiaoban pills on inflammatory response in atherosclero -sis.Methods:Use the high cholesterol diet to induce the rabbit models for 12 weeks, then fill the Jiangzhi Xi-aoban pills to the stomach for four weeks , finally detect the serum levels of ICAM -1 ,MMP-9 in the rabbits by double antibody sandwich enzyme -linked immunosorbent method and the expression levels of VEGF , ICAM-1,MMP-9 in the atherosclerotic plaques by immunohistochemical staining .Results:Compared with the model group,the Jiangzhi Xiaoban pills could decrease significantly the serum...