期刊论文

Research on the Change of Adipocytes in DIO Rats and the Intervention of the Second Pingfei Decoction

中文

中医药信息

1002-2406

2015

32

6

34-37

湖南省大学生研究性学习和创新性实验计划项目（2012）； 国家自然科学基金资助项目（No.81373717,8173551）； 湖南省科技计划资助项目（No.2012FJ4285）； 湖南省高校创新平台开放基金项目（No.12K084）；

本校为第一机构

目的：观察平肥2号方对高脂饮食诱导的单纯性肥胖大鼠体质量、脂肪细胞、肝脏等的影响。方法：50只SD大鼠随机分为低脂组和高脂组,低脂组以低脂饲料喂养,高脂组予高脂饲料喂养诱导肥胖模型。验证成模后的大鼠随机分为模型组、奥利司他组和平肥2号方组。低脂组和模型组予以蒸馏水灌胃,奥利司他和平肥2号方组分别予以奥利司他和平肥2号方灌胃。每日记录大鼠体质量,治疗4周后取材检测大鼠脂肪细胞、肝脏和血糖血脂情况。结果：平肥2号方和奥利司他组体质量增长明显低于模型组（P〈0.05）;且脂肪细胞直径变小,肝脏的脂变程度得到改善;血糖血脂水平各组无显著差异。结论：平肥2号方和奥利司他都有显著...

Objective:To observe the effect of the Second Pingfei decoction on body weight, adipocyte and liver in diet-induced obesity ( DIO ) rats.Methods:50 SD rats were randomly divided into a low fat diet group (LFD) and a high fat diet group( HFD).After the DIO models were established, the successful model rats were randomly divided into an HFD group,an Orlistat group( OLST) and the Second Pingfei decoction group ( SPFD) .LFD and HFD groups were treated with distilled water by gavage.OLST and SPFD groups were trea-ted with orlistat and the Second Pingfei decoction by gavage respectively.The body wei...