CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine

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成果类型：

期刊论文

作者：

Fan, Ping-long;Lai, Hua-qing;Wang, Hong-yun;Hu, Kai-chao;Ruan, Yuan;...

通讯作者：

Chen, NH;Chu, Shi-feng;Zhang, Zhao

作者机构：

[Lai, Hua-qing; Chen, Nai-hong; Fan, Ping-long; Chen, NH] Guangzhou Univ Chinese Med, Shenzhen Hosp Integrated Tradit Chinese & Western, Shenzhen Clin Coll Integrated Chinese & Western Me, Shenzhen, Peoples R China.

[Ye, Jun-rui; Ruan, Yuan; Yan, Xu; Chen, Nai-hong; Chu, Shi-feng; Zhang, Zhao; Chen, NH; Zhang, Z; Wang, Hong-yun; Hu, Kai-chao] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing, Peoples R China.

Chinese Acad Med Sci & Peking Union Med Coll, Neurosci Ctr, Beijing, Peoples R China.

[Peng, Ye; Chen, Nai-hong; Chen, NH; Wang, Sha-sha] Hunan Univ Chinese Med, Coll Pharm, Hunan Engn Technol Ctr Standardizat & Funct Chines, Changsha, Peoples R China.

[He, Wen-bin] Shanxi Univ Chinese Med, Natl Int Joint Res Ctr Mol Chinese Med, Taiyuan, Peoples R China.

通讯机构：

[Chu, SF; Zhang, Z] C

[Chen, NH ] G

Guangzhou Univ Chinese Med, Shenzhen Hosp Integrated Tradit Chinese & Western, Shenzhen Clin Coll Integrated Chinese & Western Me, Shenzhen, Peoples R China.

Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing, Peoples R China.

Hunan Univ Chinese Med, Coll Pharm, Hunan Engn Technol Ctr Standardizat & Funct Chines, Changsha, Peoples R China.

语种：

英文

期刊：

CELL DEATH AND DIFFERENTIATION

ISSN：

1350-9047

年：

2025

页码：

1-19

DOI：

10.1038/s41418-025-01475-x

基金类别：

National Key R&D Program of China (2022YFC3500300). National Natural Science Foundation of China (U2202214, 82074044, U21A20410, 82374060, 82130109). CAMS Innovation Fund for Medical Sciences (CIFMS) (2021-I2M-1-020).

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

Efferocytosis is crucial for the clearance of apoptotic cells (ACs) following acute ischemic stroke (AIS), however, its mechanism remains unclear. This study reveals that chemokine-like factor 1 (CKLF1) disrupts efferocytosis by promoting AC finding and internalization while impairing AC degradation in microglia. CKLF1 deficiency reduced the proportion of ACs and lowered levels of damage-associated molecular patterns. Mechanistically, CKLF1 binds to phosphatidylserine on apoptotic neurons/blebs, recruiting microglia to the ischemic penumbra via a C-C chemokine receptor 4 (CCR4)-dependent pathw...

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CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine

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