Identification of a type III polyketide synthase involved in the biosynthesis of spirolaxine

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Sun, Lei;Wang, Siyuan;Zhang, Shuwei;Yu, Dayu;Qin, Yuhui;...

通讯作者：

Zhan, Jixun;Wang, Wei

作者机构：

[Zhang, Shuwei; Yu, Dayu; Sun, Lei; Wang, Siyuan; Zhan, Jixun] Utah State Univ, Dept Biol Engn, 4105 Old Main Hill, Logan, UT 84322 USA.

[Yu, Dayu] Northeast Dianli Univ, Dept Appl Chem & Biol Engn, Coll Chem Engn, Jilin 132012, Jilin, Peoples R China.

[Wang, Wei; Zhan, Jixun; Huang, Huiyong; Qin, Yuhui] Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Zhan, Jixun] U

[Wang, W; Zhan, JX] H

Utah State Univ, Dept Biol Engn, 4105 Old Main Hill, Logan, UT 84322 USA.

Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Anti-Helicobacter pylori;Biosynthesis;Gene disruption;Spirolaxine;Type III polyketide synthase

期刊：

Applied Microbiology and Biotechnology

ISSN：

0175-7598

年：

2016

卷：

100

期：

页码：

7103-7113

DOI：

10.1007/s00253-016-7444-5

基金类别：

American Heart AssociationAmerican Heart Association [16GRNT26430067]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31170763, 31470787]; Hunan Science and Technology Key Project [2014FJ1007]; Hundred Talents Program of Hunan Province, China

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

Spirolaxine is a natural product isolated from Sporotrichum laxum ATCC 15155, which has shown a variety of biological activities including promising anti-Helicobacter pylori property. To understand how this compound is biosynthesized, the genome of S. laxum was sequenced. Analysis of the genome sequence revealed two putative type III polyketide synthase (PKS) genes in this strain, Sl-pks1 and Sl-pks2, which are located adjacent to each other (~2.0 kb apart) in a tail-to-tail arrangement. Disruption of these two genes revealed that Sl-PKS2 is the dedicated PKS involved in the biosynthesis ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Identification of a type III polyketide synthase involved in the biosynthesis of spirolaxine

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问