期刊论文

Jian, W.X.

中文

中国中西医结合杂志

1003-5370

2010

30

6

579-584

国家自然科学基金资助项目（No.30772696） 湖南省科技厅项目（No.2007FJ3071） 湖南省研究生创新基金项目（湘财教指[2008]68号）

本校为第一机构

目的 寻找冠心病(coronary heart disease,CHD)心血瘀阻证患者血浆代谢产物谱,分析CHD心血瘀阻证血浆层面的代谢途径.方法采用QP2010气相色谱一质谱联用仪(GC-MS)检测CHD心血瘀阻证组和CHD非心血瘀阻证组及健康对照组血浆代谢产物,对不同组之间代谢产物含量的变化主成分分析 (principal components analysis,PCA)、偏最小二乘法分析(partial lease squares,PLS).结果(1)主成分分析:显示3组样本主成分积分值,3组分聚于椭圆形散点图的3个区域,其中CHD心血瘀阻证组中乳酸、β-羟基丁酸、尿素、油酸、硬脂酸、花生四烯酸物质含量上调,而柠檬酸含量下调.(2)偏最小二乘法分析:显示健康组远离CHD心血瘀...

OBJECTIVE: To research the plasmic metabolites and metabolic pathway of Xin-blood stasis syndrome (XBSS). METHODS: Plasma metabolic products in patients of coronary heart disease (CHD) with XBSS or non-XBSS and subjects in the control group were identified by gas chromatographic mass spectrometry (GC-MS) type QP2010, the changes of their main elements in different groups were analyzed by principal components analysis (PCA) and partial least squares (PLS) analysis. RESULTS: PCA showed that as compared with that in the control group, in the CHD-XBSS group, contents of lactic acid, beta-hydroxy b...