期刊论文

中文

世界中医药

1673-7202

2014

9

1214-1217

10.3969/j.issn.1673-7202.2014.09.031

本校为第一机构

目的：观察加味黑地黄汤超微饮片对单侧输尿管结扎（Unilateral Ureteral Obstruction，UUO）大鼠肾脏纤维化的影响。方法：采用单侧输尿管结扎法复制单侧输尿管梗阻致大鼠肾间质纤维化模型，将其随机均分为空白组、假手术组、模型对照组、超微饮片组、尿毒清颗粒组，每组10只。加味黑地黄汤超微饮片组和尿毒清颗粒剂组分别予加味黑地黄汤超微饮片和尿毒清颗粒剂溶于4 mL 蒸馏水灌胃，空白组、假手术组和模型组均予等体积蒸馏水灌胃。在 UUO 术后第14 d，将各组大鼠处死，分别取肾组织以 TUNEL 法检测各组大鼠肾组织细胞凋亡，并检测各组大鼠血液流变学，以及血肌酐和尿素氮。结果：经过 TUNEL ...

Objective:To observe the effect of micro decoction pieces of modified Heidihuang decoction on renal fibrosis rats caused by unilateral ureteral obstruction (UUO).Methods:Rat fibrosis models were established through unilateral ureteral obstruction,then those rats were randomly divided into blank group,sham group,model control group,micro decoction pieces group,Niaoduqing group,with 10 in each group.The micro decoction pieces of modified Heidihuang decoction and Niaoduqing granules dissolved in 4ml distilled water were respectively administered intragastrically to rats in micro decoction pieces ...