期刊论文

Tan, J.

中文

中国康复医学杂志

1001-1242

2018

33

7

777-782,799

10.3969/j.issn.1001-1242.2018.07.005

湖南省教育厅优秀青年项目（16B197） 湖南省“十二五”重点学科针灸推拿学开放基金重点资助项目（2015-02）

本校为第一且通讯机构

目的:观察有氧运动对慢性缺血性认知障碍模型大鼠学习记忆能力及海马组织中磷酸化环磷腺苷反应元件结合蛋白(pCREB)、蛋白激酶C相互作用蛋白1 (PICK 1)及谷氨酸受体2 (GluR2)表达的影响,探讨其部分作用机制。方法:56只SD雄性大鼠按照随机数字表法分成4组,假手术组、模型组、药物组及有氧运动组,每组14只。模型组、药物组及有氧运动组按照双侧颈总动脉永久结扎法制备模型,所有大鼠于造模前、造模后及治疗后进行3次Morris水迷宫评估,运用尼氏染色法观察海马CA1区病理形态学改变、Western Blot法测定大鼠海马组织pCREB、PICKl及GluR2蛋白的表达情况。结果:①Morris水迷宫评估结果显示:与假手术组比...

Objective: To investigate the influence of aerobic exercise on memory ability and the expression of pCREB, PICK1 and GluR2 on hippocampus in rats with ischemic cognitive disorder. Method: Fifty- six male Sprague- Dawley rats were randomly divided into four groups: sham- operation group, model group, medicinal group and aerobics group according to the numeration table(n=10 in each group). In model group, medicinal group and aerobics group, common carotid arteries were ligated to establish the model. All groups were evaluated by Morris water maze...