期刊论文

Experimental study of electroacupuncture at"Quchi"(LI 11)-“Yanglingquan"(GB 34) on relieving the plasticity of brain synapse structure in rats with stroke

中文

中国康复医学杂志

1001-1242

2020

35

7

787-793

10.3969/j.issn.1001-1242.2020.07.005

国家自然科学基金项目(81673886) 国家重点基础研究发展计划“973”中医专项(2014CB543102) 湖南省自然科学基金项目(2018JJ2294) 湖南省中医药科研计划项目(201862) 2018年湖南省研究生科研创新项目(CX2018B488)。

本校为第一机构

目的:通过动物实验观察电针治疗对脑卒中痉挛状态下SD大鼠的神经损伤与肌张力情况,皮质运动区突触超微形态变化及大脑皮质内突触可塑性相关蛋白（synaptophysin, SYN;GABA transporter, GAT-1;post-synaptic density-95, PSD-95）表达的影响,揭示电针"曲池"-"阳陵泉"缓解痉挛的疗效及其作用机制。方法:将77只SD大鼠经两次随机分组分为电针组、假手术组、模型组、空白对照组,采用改良Zea-Longa线栓法+内囊注射NMDA受体法制备脑卒中肢体痉挛大鼠模型,行为学评分确认模型成功后,开始在双侧曲池、阳陵泉行电针治疗,每次30min,每日1次,持续5d。行为学检测神经功能与肌张力,电镜观察各组皮质突触的超微...

Objective: To observe the neurological injury of SD rats under spasticity of cerebral apoplexy(SCA) by animal electroacupuncture, to detect the changes of synaptic ultrastructural in the cortex and the expression of synaptic plasticity related proteins(SYN, GAT-1, PSD-95), to reveal the efficacy and mechanism of electroacupuncture at "Quchi"(LI 11)- "Yanglingquan"(GB 34). Method: Thirty- six Sprague-Dawley rats were randomly divided into electroacupuncture group, sham operation group, model group and blank control group. The model of limb spast...