期刊论文

中文

中国康复医学杂志

1001-1242

2022

37

4

443-450

10.3969/j.issn.1001-1242.2022.04.002

湖南省自然科学基金项目（2018JJ3384）； 湖南省中医药科研计划项目（2021233）； 湖南中医药大学医学技术一流学科开放基金项目（2018YXJS03,2021YXJS01）；

本校为第一机构

目的:探讨有氧运动训练治疗对血管性痴呆大鼠肠道菌群结构的影响.方法:选择6周龄SPF级SD雄性大鼠,使用双侧颈总动脉永久性结扎法制备血管性痴呆大鼠模型,成模后随机分为模型组(Model)、有氧运动组(Swim),另取一组为假手术组(Sham),仅分离颈总动脉不结扎),每组12只.造模4周后进行干预,Swim组予以每日不负重游泳训练20min,共4周.进行Morris水迷宫检测学习记忆能力、电镜观察海马CA1区神经元超微结构、HE染色检测结肠组织病理变化、16S rDNA测序法检测肠道菌群.结果:与Sham组比较,干预后Model组平均逃避潜伏期明显延长(P＜0.01),穿越平台次数明显减少(P＜0.05);与Model组比较,Swim组大鼠平均逃避潜...

Objective: To explore the effects of aerobic exercise training on intestinal flora constructures of rats with vascular dementia. Method: 6-week-old SPF SD male rats was included in this study and the model of vascular dementia was induced by permanent ligation of bilateral common carotid arteries. After the model was successfully established, the rats were randomly divided into model group, aerobic-exercise group and sham-operation group (carotid arteries only separated without ligation), with 12 rats in each group. After 4 weeks recovery, the ...