OBJECTIVE: Hypertension is closely associated with profound vascular remodeling, especially proliferation and hyperplasia of vascular smooth muscle cells (VSMCs). Aberrant Wnt5a signaling has been related to vascular diseases, but its role on the proliferation of VSMCs is unclear. The study evaluated the effect of Wnt5a on the proliferation of VSMCs and its possible mechanism. DESIGN AND METHOD: The capability of cell proliferation was detected by the assays of MTT, colony formation and EdU cell proliferation. Flow cytometry detections were applied to evaluate the cell cycle. The expressions o...
