Phenotypic characterization of type II collagen-induced arthritis in Wistar rats

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Song, Hou-Pan（宋厚盼）;Li, Xin（李鑫）;Yu, Rong（喻嵘）;Zeng, Guang;Yuan, Zhen-Yi（袁振仪）;...

通讯作者：

Cai, Xiong（蔡雄）

作者机构：

[Song, Hou-Pan; Li, Xin; Zeng, Guang; Huang, Hui-Yong; Cai, Xiong] Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost Chinese Med, Changsha 410007, Hunan, Peoples R China.

[Yu, Rong; Yuan, Zhen-Yi; Cai, Xiong] Hunan Univ Chinese Med, Hunan Dept, Educ Key Lab Translat Chinese Med, Changsha 410007, Hunan, Peoples R China.

[Wang, Wei] Hunan Univ Chinese Med, Sch Pharmaceut Sci, Changsha 410007, Hunan, Peoples R China.

[Cai, Xiong] Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost Chinese Med, 113C Shaoshan Rd, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Cai, Xiong] H

Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost Chinese Med, 113C Shaoshan Rd, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

Wistar rats;bovine type II collagen;collagen-induced arthritis;incomplete Freund's adjuvant

期刊：

Experimental and Therapeutic Medicine

ISSN：

1792-0981

年：

2015

卷：

期：

页码：

1483-1488

DOI：

10.3892/etm.2015.2667

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81373540]; Key Science & Research Program of Hunan Department of Science Technology [2012TF-1005]; Hunan Chinese Medicine Science & Research Key Project [201308]; Open-Ended Science Foundation of National Key Subject of Traditional Chinese Medicine Diagnostics [2013ZYZD10, 2014-8]

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

药学院

摘要：

The aim of the present study was to determine a more specific, efficient and simple method for the induction of collagen-induced arthritis (CIA) in rats. Different strains of rats were injected at the base of the tail with bovine type II collagen (CII) emulsified in incomplete Freund's adjuvant (IFA). The onset and severity of arthritis were evaluated by clinical assessment. The established CIA model was analyzed using a comprehensive examination of clinical, hematological, histological and radiological parameters. The results demonstrated that...

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Phenotypic characterization of type II collagen-induced arthritis in Wistar rats

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