期刊论文

中文

北京中医药大学学报

1006-2157

2006

29

7

457-460

10.3321/j.issn:1006-2157.2006.07.007

中国博士后科学基金项目（No．2003033474）； 中南大学博士后基金项目； 湖南省卫生厅项目（No．204044）；

本校为其他机构

目的 观察茵陈五苓散对动脉粥样硬化(AS)大鼠血管平滑肌细胞(VSMC)肌动蛋白表达的影响.方法 70只Wistar大鼠随机分为正常组、模型组、茵陈五苓散组、胶股蓝组.采用高脂饲料喂饲法复制大鼠动脉粥样硬化模型,造模1个月后抽样检测大鼠主动脉,以发现动脉粥样硬化斑块为造模成功指标.治疗1个月后分别检测血脂、血液流变学,用HE染色观察主动脉组织学变化,用透射电镜观察大鼠主动脉组织超微结构变化,用免疫组化法观察大鼠主动脉VSMC肌动蛋白的变化.结果 茵陈五苓散对动AS模型大鼠有明显的降脂作用,能改善血液流变性、消退斑块、维持主动脉组织结构及功能,使细胞肌动蛋白表达趋于正常.结论 茵陈五苓散具...

Objective To observe the influence of Yinchenwulin Powder on actin expression of vascular smooth muscle cell （VSMC） in rats with atherosclerosis （AS）. Methods To divide randomly 70 Wistar rats into the normal group, model group, Yinchenwulin Powder group and Gypenosides Tablets group. The AS rat model was established by feeding with high grease food and atherosclerosis plaque was found in aorta of rat sample after one mouth, which was the successful index of model establishment. The level of serum lipid and hemorheology were detected after ...